Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program

Peter Izmirly, Jill Buyon, H. Michael Belmont, Sara Sahl, Isabella Wan, Jane Salmon, Anca Askanase, Joan M. Bathon, Laura Geraldino-Pardilla, Yusaf Ali, Ellen Ginzler, Chaim Putterman, Caroline Gordon, Charles Helmick, Hilary Parton

Research output: Contribution to journalArticle

Abstract

Objective Epidemiological data for primary discoid lupus erythematosus (pDLE) remain limited, particularly for racial/ethnic populations in the USA. The Manhattan Lupus Surveillance Program (MLSP) is a population-based retrospective registry of cases with SLE and related diseases including pDLE in Manhattan and was used to provide estimates of the prevalence and incidence of pDLE across major racial/ethnic populations. Methods MLSP cases were identified from rheumatologists, hospitals and population databases. Two case definitions were used for pDLE: the primary case definition which was any physician diagnosis found in the chart and a secondary case definition which was limited to cases diagnosed by a rheumatologist and/or dermatologist. Rates among Manhattan residents were age-adjusted, and capture-recapture analyses were conducted to assess case under-ascertainment. Results Based on the primary definition, age-adjusted overall prevalence and incidence rates of pDLE among Manhattan residents were 6.5 and 0.8 per 100 000 person-years, which increased to 9.0 and 1.3 after capture-recapture adjustment. Prevalence and incidence rates were approximately two and six times higher, respectively, among women compared with men (p<0.0001). Higher prevalence was also found among non-Latino blacks (23.5) and Latinos (8.2) compared with non-Latino whites (1.8) and non-Latino Asians (0.6) (p<0.0001). Incidence was highest among non-Latino blacks (2.4) compared with all other racial/ethnic groups. Similar relationships were observed for the secondary case definition. Conclusion Data from the MLSP provide epidemiological estimates for pDLE among the major racial/ethnic populations in the USA and reveal disparities in pDLE prevalence and incidence by sex and race/ethnicity among Manhattan residents.

Original languageEnglish (US)
Article numbere000344
JournalLupus Science and Medicine
Volume6
Issue number1
DOIs
StatePublished - Oct 1 2019

Fingerprint

Discoid Lupus Erythematosus
Incidence
Population
Hispanic Americans
Ethnic Groups
Registries
Databases
Physicians

Keywords

  • Discoid Lupus Erythematosus
  • epidemiology
  • Registry

ASJC Scopus subject areas

  • Immunology

Cite this

Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program. / Izmirly, Peter; Buyon, Jill; Belmont, H. Michael; Sahl, Sara; Wan, Isabella; Salmon, Jane; Askanase, Anca; Bathon, Joan M.; Geraldino-Pardilla, Laura; Ali, Yusaf; Ginzler, Ellen; Putterman, Chaim; Gordon, Caroline; Helmick, Charles; Parton, Hilary.

In: Lupus Science and Medicine, Vol. 6, No. 1, e000344, 01.10.2019.

Research output: Contribution to journalArticle

Izmirly, P, Buyon, J, Belmont, HM, Sahl, S, Wan, I, Salmon, J, Askanase, A, Bathon, JM, Geraldino-Pardilla, L, Ali, Y, Ginzler, E, Putterman, C, Gordon, C, Helmick, C & Parton, H 2019, 'Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program', Lupus Science and Medicine, vol. 6, no. 1, e000344. https://doi.org/10.1136/lupus-2019-000344
Izmirly, Peter ; Buyon, Jill ; Belmont, H. Michael ; Sahl, Sara ; Wan, Isabella ; Salmon, Jane ; Askanase, Anca ; Bathon, Joan M. ; Geraldino-Pardilla, Laura ; Ali, Yusaf ; Ginzler, Ellen ; Putterman, Chaim ; Gordon, Caroline ; Helmick, Charles ; Parton, Hilary. / Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program. In: Lupus Science and Medicine. 2019 ; Vol. 6, No. 1.
@article{a994176a0c1849c49e0f854028ffc3fe,
title = "Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program",
abstract = "Objective Epidemiological data for primary discoid lupus erythematosus (pDLE) remain limited, particularly for racial/ethnic populations in the USA. The Manhattan Lupus Surveillance Program (MLSP) is a population-based retrospective registry of cases with SLE and related diseases including pDLE in Manhattan and was used to provide estimates of the prevalence and incidence of pDLE across major racial/ethnic populations. Methods MLSP cases were identified from rheumatologists, hospitals and population databases. Two case definitions were used for pDLE: the primary case definition which was any physician diagnosis found in the chart and a secondary case definition which was limited to cases diagnosed by a rheumatologist and/or dermatologist. Rates among Manhattan residents were age-adjusted, and capture-recapture analyses were conducted to assess case under-ascertainment. Results Based on the primary definition, age-adjusted overall prevalence and incidence rates of pDLE among Manhattan residents were 6.5 and 0.8 per 100 000 person-years, which increased to 9.0 and 1.3 after capture-recapture adjustment. Prevalence and incidence rates were approximately two and six times higher, respectively, among women compared with men (p<0.0001). Higher prevalence was also found among non-Latino blacks (23.5) and Latinos (8.2) compared with non-Latino whites (1.8) and non-Latino Asians (0.6) (p<0.0001). Incidence was highest among non-Latino blacks (2.4) compared with all other racial/ethnic groups. Similar relationships were observed for the secondary case definition. Conclusion Data from the MLSP provide epidemiological estimates for pDLE among the major racial/ethnic populations in the USA and reveal disparities in pDLE prevalence and incidence by sex and race/ethnicity among Manhattan residents.",
keywords = "Discoid Lupus Erythematosus, epidemiology, Registry",
author = "Peter Izmirly and Jill Buyon and Belmont, {H. Michael} and Sara Sahl and Isabella Wan and Jane Salmon and Anca Askanase and Bathon, {Joan M.} and Laura Geraldino-Pardilla and Yusaf Ali and Ellen Ginzler and Chaim Putterman and Caroline Gordon and Charles Helmick and Hilary Parton",
year = "2019",
month = "10",
day = "1",
doi = "10.1136/lupus-2019-000344",
language = "English (US)",
volume = "6",
journal = "Lupus Science and Medicine",
issn = "2053-8790",
publisher = "BMJ Publishing Group",
number = "1",

}

TY - JOUR

T1 - Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program

AU - Izmirly, Peter

AU - Buyon, Jill

AU - Belmont, H. Michael

AU - Sahl, Sara

AU - Wan, Isabella

AU - Salmon, Jane

AU - Askanase, Anca

AU - Bathon, Joan M.

AU - Geraldino-Pardilla, Laura

AU - Ali, Yusaf

AU - Ginzler, Ellen

AU - Putterman, Chaim

AU - Gordon, Caroline

AU - Helmick, Charles

AU - Parton, Hilary

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Objective Epidemiological data for primary discoid lupus erythematosus (pDLE) remain limited, particularly for racial/ethnic populations in the USA. The Manhattan Lupus Surveillance Program (MLSP) is a population-based retrospective registry of cases with SLE and related diseases including pDLE in Manhattan and was used to provide estimates of the prevalence and incidence of pDLE across major racial/ethnic populations. Methods MLSP cases were identified from rheumatologists, hospitals and population databases. Two case definitions were used for pDLE: the primary case definition which was any physician diagnosis found in the chart and a secondary case definition which was limited to cases diagnosed by a rheumatologist and/or dermatologist. Rates among Manhattan residents were age-adjusted, and capture-recapture analyses were conducted to assess case under-ascertainment. Results Based on the primary definition, age-adjusted overall prevalence and incidence rates of pDLE among Manhattan residents were 6.5 and 0.8 per 100 000 person-years, which increased to 9.0 and 1.3 after capture-recapture adjustment. Prevalence and incidence rates were approximately two and six times higher, respectively, among women compared with men (p<0.0001). Higher prevalence was also found among non-Latino blacks (23.5) and Latinos (8.2) compared with non-Latino whites (1.8) and non-Latino Asians (0.6) (p<0.0001). Incidence was highest among non-Latino blacks (2.4) compared with all other racial/ethnic groups. Similar relationships were observed for the secondary case definition. Conclusion Data from the MLSP provide epidemiological estimates for pDLE among the major racial/ethnic populations in the USA and reveal disparities in pDLE prevalence and incidence by sex and race/ethnicity among Manhattan residents.

AB - Objective Epidemiological data for primary discoid lupus erythematosus (pDLE) remain limited, particularly for racial/ethnic populations in the USA. The Manhattan Lupus Surveillance Program (MLSP) is a population-based retrospective registry of cases with SLE and related diseases including pDLE in Manhattan and was used to provide estimates of the prevalence and incidence of pDLE across major racial/ethnic populations. Methods MLSP cases were identified from rheumatologists, hospitals and population databases. Two case definitions were used for pDLE: the primary case definition which was any physician diagnosis found in the chart and a secondary case definition which was limited to cases diagnosed by a rheumatologist and/or dermatologist. Rates among Manhattan residents were age-adjusted, and capture-recapture analyses were conducted to assess case under-ascertainment. Results Based on the primary definition, age-adjusted overall prevalence and incidence rates of pDLE among Manhattan residents were 6.5 and 0.8 per 100 000 person-years, which increased to 9.0 and 1.3 after capture-recapture adjustment. Prevalence and incidence rates were approximately two and six times higher, respectively, among women compared with men (p<0.0001). Higher prevalence was also found among non-Latino blacks (23.5) and Latinos (8.2) compared with non-Latino whites (1.8) and non-Latino Asians (0.6) (p<0.0001). Incidence was highest among non-Latino blacks (2.4) compared with all other racial/ethnic groups. Similar relationships were observed for the secondary case definition. Conclusion Data from the MLSP provide epidemiological estimates for pDLE among the major racial/ethnic populations in the USA and reveal disparities in pDLE prevalence and incidence by sex and race/ethnicity among Manhattan residents.

KW - Discoid Lupus Erythematosus

KW - epidemiology

KW - Registry

UR - http://www.scopus.com/inward/record.url?scp=85074586108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074586108&partnerID=8YFLogxK

U2 - 10.1136/lupus-2019-000344

DO - 10.1136/lupus-2019-000344

M3 - Article

AN - SCOPUS:85074586108

VL - 6

JO - Lupus Science and Medicine

JF - Lupus Science and Medicine

SN - 2053-8790

IS - 1

M1 - e000344

ER -