Pooling data when analyzing biomarkers subject to a limit of detection

Leslie Rosenthal, Enrique Schisterman

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The use of biomarkers to assess exposure and investigate biomedical questions is common in epidemiology. The usefulness of biomarker research, however, is contingent upon the ability to achieve a complete understanding of the role they play within a population. In estimating distributional parameters for a particular biomarker, such as oxidative stress or antioxidant markers, scientists face two main challenges: overcoming the cost of performing a large number of assays and dealing with data subject to a limit of detection. While approaches have been suggested to deal with each of these issues individually, pooling is a strategy that can address both problems.

Original languageEnglish (US)
Title of host publicationAdvanced Protocols in Oxidative Stress I
EditorsDonald Armstrong, Donald Armstrong, Donald Armstrong
Pages421-426
Number of pages6
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume477
ISSN (Print)1064-3745

Keywords

  • Biomarkers
  • Detection limit
  • Pooling

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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