Polypeptide growth factors in the nucleus: A review of function and translocation

Jason E. Levine, Michael B. Prystowsky

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Conventional wisdom declares that polypeptide growth factors act solely by binding to the cell surface and transducing a signal through receptor-mediated kinase cascades; following this, they are endocytosed and degraded. Recent evidence, however, has demonstrated that several growth factors bind to the cell surface and are translocated into the nucleus. Furthermore, these growth factors exert biochemical function within the nucleus. Here we review the growth factors which translocate to the nucleus and/or exert biochemical function within the nucleus, and propose possible translocation mechanisms, including retrograde transport from the cell surface to the nuclear envelope.

Original languageEnglish (US)
Pages (from-to)290-298
Number of pages9
JournalNeuroImmunoModulation
Volume2
Issue number5
DOIs
Publication statusPublished - Jan 1 1995

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Keywords

  • Nuclear translocation
  • Polypeptide growth factors
  • Receptor-mediated endocytosis
  • Retrograde transport

ASJC Scopus subject areas

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems

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