Polymorphisms of the human leukocyte antigen DRB1 and DQB1 genes and the natural history of human papillomavirus infection

Paulo C. Maciag, Nicolas F. Schlecht, Patricia S A Souza, Thomas E. Rohan, Eduardo L. Franco, Luisa L. Villa

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

This study investigated, through cohort analysis, whether HLA-DRB1 and -DQB1 variability is related to human papillomavirus (HPV) infection prevalence and persistence. HLA-DRB1 and -DQB1 genes were typed in 620 samples from the Ludwig-McGill cohort. HPV positivity was tested in specimens collected every 4 months during the first year of follow-up. Persistent and long-term infections were defined as at least 2 or 3 consecutive positive results for the same HPV type, respectively. The magnitudes of associations were estimated by unconditional logistic regression analysis adjusted for potential confounders. The DRB1*0301-DQB1*0201 haplotype was associated with a 2-fold reduction in risk for transient and persistent HPV infections. DRB1*1102-DQB1*0301 showed a lower-risk effect only for persistence. DRB1*1601-DQB1*0502 and DRB1*0807-DQB1*0402 were associated with a 7-fold and a 3-fold increase, respectively, in risk for persistence. The results suggest that HLA class II polymorphisms are involved in clearance and maintenance of HPV infection.

Original languageEnglish (US)
Pages (from-to)164-172
Number of pages9
JournalJournal of Infectious Diseases
Volume186
Issue number2
DOIs
StatePublished - Jul 15 2002

Fingerprint

Papillomavirus Infections
HLA Antigens
HLA-DRB1 Chains
Genes
Risk Reduction Behavior
Haplotypes
Cohort Studies
Logistic Models
Regression Analysis
Maintenance
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Polymorphisms of the human leukocyte antigen DRB1 and DQB1 genes and the natural history of human papillomavirus infection. / Maciag, Paulo C.; Schlecht, Nicolas F.; Souza, Patricia S A; Rohan, Thomas E.; Franco, Eduardo L.; Villa, Luisa L.

In: Journal of Infectious Diseases, Vol. 186, No. 2, 15.07.2002, p. 164-172.

Research output: Contribution to journalArticle

Maciag, Paulo C. ; Schlecht, Nicolas F. ; Souza, Patricia S A ; Rohan, Thomas E. ; Franco, Eduardo L. ; Villa, Luisa L. / Polymorphisms of the human leukocyte antigen DRB1 and DQB1 genes and the natural history of human papillomavirus infection. In: Journal of Infectious Diseases. 2002 ; Vol. 186, No. 2. pp. 164-172.
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