Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma

Wei Hu; Bryan A. Bassig; Jun Xu; Tongzhang Zheng; Yawei Zhang; Sonja I. Berndt; Theodore R. Holford; H. Dean Hosgood; Brian Leaderer; Meredith Yeager; Idan Menashe; Peter Boyle; Kaiyong Zou; Yong Zhu; Stephen Chanock; Qing Lan; Nathaniel Rothman

doi:10.1002/em.21739

Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma

Wei Hu, Bryan A. Bassig, Jun Xu, Tongzhang Zheng, Yawei Zhang, Sonja I. Berndt, Theodore R. Holford, H. Dean Hosgood, Brian Leaderer, Meredith Yeager, Idan Menashe, Peter Boyle, Kaiyong Zou, Yong Zhu, Stephen Chanock, Qing Lan, Nathaniel Rothman

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The pattern-recognition pathway plays an important role in infection recognition and immune responses, and previous studies have suggested an association between genetic variation in innate immunity genes and non-Hodgkin lymphoma (NHL). We evaluated NHL risk associated with genetic variation in pattern-recognition genes using data from a case-control study of NHL conducted in Connecticut women. Single nucleotide polymorphisms (SNPs) in 27 pattern-recognition genes were genotyped in 432 Caucasian incident NHL cases and 494 frequency-matched controls. Unconditional logistic regression was used to compute odds ratios (ORs) for NHL and common NHL subtypes in relation to individual SNPs and haplotypes. A gene-based analysis that adjusted for the number of tagSNPs genotyped in each gene showed a significant association with overall NHL for the MBP gene (P = 0.028), with the diffuse large B-cell lymphoma (DLBCL) subtype for the MASP2 gene (P = 0.011), and with the follicular lymphoma (FL) subtype for DEFB126 (P = 0.041). A SNP-based analysis showed that MBP rs8094402 was associated with decreased risks of overall NHL (allele risk OR = 0.72, P-trend = 0.0018), DLBCL (allele risk OR = 0.72, P-trend = 0.036), and FL (allele risk OR = 0.67, P-trend = 0.021), while MASP2 rs12711521 was associated with a decreased risk of DLBCL (allele risk OR = 0.57, P-trend = 0.0042). We also observed an increased risk of FL for DEFB126 rs6054706 (allele risk OR = 1.39, P-trend = 0.033). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NHL or specific NHL subtypes, but these preliminary findings require replication in larger studies.

Original language	English (US)
Pages (from-to)	72-77
Number of pages	6
Journal	Environmental and Molecular Mutagenesis
Volume	54
Issue number	1
DOIs	https://doi.org/10.1002/em.21739
State	Published - Jan 2013
Externally published	Yes

Keywords

Innate immunity
MASP2
MBP
NHL
Pattern recognition

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)
Health, Toxicology and Mutagenesis

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10.1002/em.21739

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Hu, W., Bassig, B. A., Xu, J., Zheng, T., Zhang, Y., Berndt, S. I., Holford, T. R., Hosgood, H. D., Leaderer, B., Yeager, M., Menashe, I., Boyle, P., Zou, K., Zhu, Y., Chanock, S., Lan, Q., & Rothman, N. (2013). Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma. Environmental and Molecular Mutagenesis, 54(1), 72-77. https://doi.org/10.1002/em.21739

Hu, W, Bassig, BA, Xu, J, Zheng, T, Zhang, Y, Berndt, SI, Holford, TR, Hosgood, HD, Leaderer, B, Yeager, M, Menashe, I, Boyle, P, Zou, K, Zhu, Y, Chanock, S, Lan, Q & Rothman, N 2013, 'Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma', Environmental and Molecular Mutagenesis, vol. 54, no. 1, pp. 72-77. https://doi.org/10.1002/em.21739

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abstract = "The pattern-recognition pathway plays an important role in infection recognition and immune responses, and previous studies have suggested an association between genetic variation in innate immunity genes and non-Hodgkin lymphoma (NHL). We evaluated NHL risk associated with genetic variation in pattern-recognition genes using data from a case-control study of NHL conducted in Connecticut women. Single nucleotide polymorphisms (SNPs) in 27 pattern-recognition genes were genotyped in 432 Caucasian incident NHL cases and 494 frequency-matched controls. Unconditional logistic regression was used to compute odds ratios (ORs) for NHL and common NHL subtypes in relation to individual SNPs and haplotypes. A gene-based analysis that adjusted for the number of tagSNPs genotyped in each gene showed a significant association with overall NHL for the MBP gene (P = 0.028), with the diffuse large B-cell lymphoma (DLBCL) subtype for the MASP2 gene (P = 0.011), and with the follicular lymphoma (FL) subtype for DEFB126 (P = 0.041). A SNP-based analysis showed that MBP rs8094402 was associated with decreased risks of overall NHL (allele risk OR = 0.72, P-trend = 0.0018), DLBCL (allele risk OR = 0.72, P-trend = 0.036), and FL (allele risk OR = 0.67, P-trend = 0.021), while MASP2 rs12711521 was associated with a decreased risk of DLBCL (allele risk OR = 0.57, P-trend = 0.0042). We also observed an increased risk of FL for DEFB126 rs6054706 (allele risk OR = 1.39, P-trend = 0.033). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NHL or specific NHL subtypes, but these preliminary findings require replication in larger studies.",

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AU - Berndt, Sonja I.

AU - Holford, Theodore R.

AU - Hosgood, H. Dean

AU - Leaderer, Brian

AU - Yeager, Meredith

AU - Menashe, Idan

AU - Boyle, Peter

AU - Zou, Kaiyong

AU - Zhu, Yong

AU - Chanock, Stephen

AU - Lan, Qing

AU - Rothman, Nathaniel

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Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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