Polycystin-1 induced apoptosis and cell cycle arrest in G0/G1 phase in cancer cells

Rong Zheng, Zheng Zhang, Xiaoyan Lv, Jun Ming Fan, Ye Chen, Yidong Wang, Ruizhi Tan, Yuhang Liu, Qin Zhou

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Studies have shown that polycystin-1, encoded by PKD1, the major ADPKD, may have a central role in regulating both apoptosis and proliferation, which could prevent the malignant transformation of affected cells. However, as a putative tumor suppressor, direct studies on the possibility that polycystin-1 may play a role in cancer cells' biological properties have not yet been reported. We have demonstrated that the apoptosis of cancer cells was induced by overexpression of polycystin-1. After transfection with polycystin-1, three cancer cell lines, HepG2, A549, and SW480, showed significantly increased apoptosis compared with the respective control groups. This was accompanied by cell cycle arrest at G0/G1 phase, whereas cell proliferation was not significantly affected. Overexpression of polycystin-1 induces apoptosis in cancer cells, at least partially, through Wnt and a caspase-dependent pathway.

Original languageEnglish (US)
Pages (from-to)427-435
Number of pages9
JournalCell Biology International
Volume32
Issue number4
DOIs
StatePublished - Apr 1 2008

Keywords

  • Apoptosis
  • Cell cycle
  • Polycystin-1
  • Proliferation
  • Wnt pathway

ASJC Scopus subject areas

  • Cell Biology

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    Zheng, R., Zhang, Z., Lv, X., Fan, J. M., Chen, Y., Wang, Y., Tan, R., Liu, Y., & Zhou, Q. (2008). Polycystin-1 induced apoptosis and cell cycle arrest in G0/G1 phase in cancer cells. Cell Biology International, 32(4), 427-435. https://doi.org/10.1016/j.cellbi.2007.12.014