Polycystin-1 induced apoptosis and cell cycle arrest in G0/G1 phase in cancer cells

Rong Zheng, Zheng Zhang, Xiaoyan Lv, JunMing Fan, Ye Chen, Yidong Wang, Ruizhi Tan, Yuhang Liu, Qin Zhou

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Studies have shown that polycystin-1, encoded by PKD1, the major ADPKD, may have a central role in regulating both apoptosis and proliferation, which could prevent the malignant transformation of affected cells. However, as a putative tumor suppressor, direct studies on the possibility that polycystin-1 may play a role in cancer cells' biological properties have not yet been reported. We have demonstrated that the apoptosis of cancer cells was induced by overexpression of polycystin-1. After transfection with polycystin-1, three cancer cell lines, HepG2, A549, and SW480, showed significantly increased apoptosis compared with the respective control groups. This was accompanied by cell cycle arrest at G0/G1 phase, whereas cell proliferation was not significantly affected. Overexpression of polycystin-1 induces apoptosis in cancer cells, at least partially, through Wnt and a caspase-dependent pathway.

Original languageEnglish (US)
Pages (from-to)427-435
Number of pages9
JournalCell Biology International
Volume32
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Fingerprint

Cell Cycle Resting Phase
G1 Phase
Cell Cycle Checkpoints
Apoptosis
Neoplasms
Autosomal Dominant Polycystic Kidney
Caspases
Transfection
Cell Proliferation
polycystic kidney disease 1 protein
Control Groups

Keywords

  • Apoptosis
  • Cell cycle
  • Polycystin-1
  • Proliferation
  • Wnt pathway

ASJC Scopus subject areas

  • Cell Biology

Cite this

Polycystin-1 induced apoptosis and cell cycle arrest in G0/G1 phase in cancer cells. / Zheng, Rong; Zhang, Zheng; Lv, Xiaoyan; Fan, JunMing; Chen, Ye; Wang, Yidong; Tan, Ruizhi; Liu, Yuhang; Zhou, Qin.

In: Cell Biology International, Vol. 32, No. 4, 04.2008, p. 427-435.

Research output: Contribution to journalArticle

Zheng, R, Zhang, Z, Lv, X, Fan, J, Chen, Y, Wang, Y, Tan, R, Liu, Y & Zhou, Q 2008, 'Polycystin-1 induced apoptosis and cell cycle arrest in G0/G1 phase in cancer cells', Cell Biology International, vol. 32, no. 4, pp. 427-435. https://doi.org/10.1016/j.cellbi.2007.12.014
Zheng, Rong ; Zhang, Zheng ; Lv, Xiaoyan ; Fan, JunMing ; Chen, Ye ; Wang, Yidong ; Tan, Ruizhi ; Liu, Yuhang ; Zhou, Qin. / Polycystin-1 induced apoptosis and cell cycle arrest in G0/G1 phase in cancer cells. In: Cell Biology International. 2008 ; Vol. 32, No. 4. pp. 427-435.
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