TY - JOUR
T1 - Polycystin-1 induced apoptosis and cell cycle arrest in G0/G1 phase in cancer cells
AU - Zheng, Rong
AU - Zhang, Zheng
AU - Lv, Xiaoyan
AU - Fan, Jun Ming
AU - Chen, Ye
AU - Wang, Yidong
AU - Tan, Ruizhi
AU - Liu, Yuhang
AU - Zhou, Qin
N1 - Funding Information:
This work was supported by a grant of the National Key Basic Research Program of China to Qin Zhou (2005CB522506). Dr. Qin Zhou was a recipient of the Initial Foundation of M.O.E. for Returned Overseas Students (20071108-18-18) and a scholarship of the Creative Foundation of Sichuan University. The work was also supported by a grant of the S&T Bureau of Sichuan Province to Qin Zhou.
PY - 2008/4
Y1 - 2008/4
N2 - Studies have shown that polycystin-1, encoded by PKD1, the major ADPKD, may have a central role in regulating both apoptosis and proliferation, which could prevent the malignant transformation of affected cells. However, as a putative tumor suppressor, direct studies on the possibility that polycystin-1 may play a role in cancer cells' biological properties have not yet been reported. We have demonstrated that the apoptosis of cancer cells was induced by overexpression of polycystin-1. After transfection with polycystin-1, three cancer cell lines, HepG2, A549, and SW480, showed significantly increased apoptosis compared with the respective control groups. This was accompanied by cell cycle arrest at G0/G1 phase, whereas cell proliferation was not significantly affected. Overexpression of polycystin-1 induces apoptosis in cancer cells, at least partially, through Wnt and a caspase-dependent pathway.
AB - Studies have shown that polycystin-1, encoded by PKD1, the major ADPKD, may have a central role in regulating both apoptosis and proliferation, which could prevent the malignant transformation of affected cells. However, as a putative tumor suppressor, direct studies on the possibility that polycystin-1 may play a role in cancer cells' biological properties have not yet been reported. We have demonstrated that the apoptosis of cancer cells was induced by overexpression of polycystin-1. After transfection with polycystin-1, three cancer cell lines, HepG2, A549, and SW480, showed significantly increased apoptosis compared with the respective control groups. This was accompanied by cell cycle arrest at G0/G1 phase, whereas cell proliferation was not significantly affected. Overexpression of polycystin-1 induces apoptosis in cancer cells, at least partially, through Wnt and a caspase-dependent pathway.
KW - Apoptosis
KW - Cell cycle
KW - Polycystin-1
KW - Proliferation
KW - Wnt pathway
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U2 - 10.1016/j.cellbi.2007.12.014
DO - 10.1016/j.cellbi.2007.12.014
M3 - Article
C2 - 18289888
AN - SCOPUS:42749093528
SN - 1065-6995
VL - 32
SP - 427
EP - 435
JO - Cell Biology International
JF - Cell Biology International
IS - 4
ER -
