Polybrominated Diphenyl Ethers (PBDEs)

L. G. Costa, G. Giordano, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Polybrominated diphenyl ethers (PBDEs) are flame retardants used in a variety of consumer products, which have become ubiquitous environmental contaminants. Concentrations of PBDEs are particularly high in breast milk, resulting in high exposure of infants; for toddlers, dust has been estimated to account for a large percentage of exposure. PBDEs can also cross the placenta, as they have been detected in fetal blood and liver. Tetra-, penta-, and hexa-BDEs are most commonly present in human tissues. The current greatest concern for potential adverse effects of PBDEs relates to their developmental neurotoxicity, particularly in the domains of locomotor activity and cognition. Alterations in circulating thyroid hormone homeostasis and direct effects of PBDEs on the developing brain may represent underlying mechanisms.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Pages915-916
Number of pages2
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014

Fingerprint

Halogenated Diphenyl Ethers
Flame Retardants
Rubiaceae
Human Milk
Locomotion
Dust
Fetal Blood
Thyroid Hormones
Cognition
Placenta
Homeostasis
Liver
Brain

Keywords

  • BDE-209
  • BDE-47
  • BDE-99
  • Developmental neurotoxicity
  • Oxidative stress
  • Polybrominated diphenyl ethers
  • Thyroid hormone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Costa, L. G., Giordano, G., & Aschner, M. (2014). Polybrominated Diphenyl Ethers (PBDEs). In Encyclopedia of the Neurological Sciences (pp. 915-916). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00272-4

Polybrominated Diphenyl Ethers (PBDEs). / Costa, L. G.; Giordano, G.; Aschner, Michael.

Encyclopedia of the Neurological Sciences. Elsevier Inc., 2014. p. 915-916.

Research output: Chapter in Book/Report/Conference proceedingChapter

Costa, LG, Giordano, G & Aschner, M 2014, Polybrominated Diphenyl Ethers (PBDEs). in Encyclopedia of the Neurological Sciences. Elsevier Inc., pp. 915-916. https://doi.org/10.1016/B978-0-12-385157-4.00272-4
Costa LG, Giordano G, Aschner M. Polybrominated Diphenyl Ethers (PBDEs). In Encyclopedia of the Neurological Sciences. Elsevier Inc. 2014. p. 915-916 https://doi.org/10.1016/B978-0-12-385157-4.00272-4
Costa, L. G. ; Giordano, G. ; Aschner, Michael. / Polybrominated Diphenyl Ethers (PBDEs). Encyclopedia of the Neurological Sciences. Elsevier Inc., 2014. pp. 915-916
@inbook{1c6567afa267496a92a7f9d883a6f7dc,
title = "Polybrominated Diphenyl Ethers (PBDEs)",
abstract = "Polybrominated diphenyl ethers (PBDEs) are flame retardants used in a variety of consumer products, which have become ubiquitous environmental contaminants. Concentrations of PBDEs are particularly high in breast milk, resulting in high exposure of infants; for toddlers, dust has been estimated to account for a large percentage of exposure. PBDEs can also cross the placenta, as they have been detected in fetal blood and liver. Tetra-, penta-, and hexa-BDEs are most commonly present in human tissues. The current greatest concern for potential adverse effects of PBDEs relates to their developmental neurotoxicity, particularly in the domains of locomotor activity and cognition. Alterations in circulating thyroid hormone homeostasis and direct effects of PBDEs on the developing brain may represent underlying mechanisms.",
keywords = "BDE-209, BDE-47, BDE-99, Developmental neurotoxicity, Oxidative stress, Polybrominated diphenyl ethers, Thyroid hormone",
author = "Costa, {L. G.} and G. Giordano and Michael Aschner",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/B978-0-12-385157-4.00272-4",
language = "English (US)",
isbn = "9780123851581",
pages = "915--916",
booktitle = "Encyclopedia of the Neurological Sciences",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Polybrominated Diphenyl Ethers (PBDEs)

AU - Costa, L. G.

AU - Giordano, G.

AU - Aschner, Michael

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Polybrominated diphenyl ethers (PBDEs) are flame retardants used in a variety of consumer products, which have become ubiquitous environmental contaminants. Concentrations of PBDEs are particularly high in breast milk, resulting in high exposure of infants; for toddlers, dust has been estimated to account for a large percentage of exposure. PBDEs can also cross the placenta, as they have been detected in fetal blood and liver. Tetra-, penta-, and hexa-BDEs are most commonly present in human tissues. The current greatest concern for potential adverse effects of PBDEs relates to their developmental neurotoxicity, particularly in the domains of locomotor activity and cognition. Alterations in circulating thyroid hormone homeostasis and direct effects of PBDEs on the developing brain may represent underlying mechanisms.

AB - Polybrominated diphenyl ethers (PBDEs) are flame retardants used in a variety of consumer products, which have become ubiquitous environmental contaminants. Concentrations of PBDEs are particularly high in breast milk, resulting in high exposure of infants; for toddlers, dust has been estimated to account for a large percentage of exposure. PBDEs can also cross the placenta, as they have been detected in fetal blood and liver. Tetra-, penta-, and hexa-BDEs are most commonly present in human tissues. The current greatest concern for potential adverse effects of PBDEs relates to their developmental neurotoxicity, particularly in the domains of locomotor activity and cognition. Alterations in circulating thyroid hormone homeostasis and direct effects of PBDEs on the developing brain may represent underlying mechanisms.

KW - BDE-209

KW - BDE-47

KW - BDE-99

KW - Developmental neurotoxicity

KW - Oxidative stress

KW - Polybrominated diphenyl ethers

KW - Thyroid hormone

UR - http://www.scopus.com/inward/record.url?scp=85043238607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043238607&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-385157-4.00272-4

DO - 10.1016/B978-0-12-385157-4.00272-4

M3 - Chapter

AN - SCOPUS:85043238607

SN - 9780123851581

SP - 915

EP - 916

BT - Encyclopedia of the Neurological Sciences

PB - Elsevier Inc.

ER -