POLINA: Detection and evaluation of single amino acid substitutions in protein superfamilies

Sergei Levin; Birgit H. Satir

doi:10.1093/bioinformatics/14.4.374

POLINA: Detection and evaluation of single amino acid substitutions in protein superfamilies

Sergei Levin, Birgit H. Satir

Anatomy & Structural Biology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Motivation and results: An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program. Availability: A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.html. Contact: slevin@@@aecom.yu.edu; bsatir@@@aecom.yu.edu.

Original language	English (US)
Pages (from-to)	374-375
Number of pages	2
Journal	Bioinformatics
Volume	14
Issue number	4
DOIs	https://doi.org/10.1093/bioinformatics/14.4.374
State	Published - 1998

ASJC Scopus subject areas

Statistics and Probability
Biochemistry
Molecular Biology
Computer Science Applications
Computational Theory and Mathematics
Computational Mathematics

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AU - Satir, Birgit H.

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AB - Motivation and results: An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program. Availability: A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.html. Contact: slevin@@@aecom.yu.edu; bsatir@@@aecom.yu.edu.

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POLINA: Detection and evaluation of single amino acid substitutions in protein superfamilies

Abstract

ASJC Scopus subject areas

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