Abstract
Motivation and results: An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program. Availability: A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.html. Contact: slevin@@@aecom.yu.edu; bsatir@@@aecom.yu.edu.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 374-375 |
| Number of pages | 2 |
| Journal | Bioinformatics |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1998 |
ASJC Scopus subject areas
- Statistics and Probability
- Biochemistry
- Molecular Biology
- Computer Science Applications
- Computational Theory and Mathematics
- Computational Mathematics
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Levin, S., & Satir, B. H. (1998). POLINA: Detection and evaluation of single amino acid substitutions in protein superfamilies. Bioinformatics, 14(4), 374-375. https://doi.org/10.1093/bioinformatics/14.4.374