POLINA

Detection and evaluation of single amino acid substitutions in protein superfamilies

Sergei Levin, Birgit H. Satir

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Motivation and results: An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program. Availability: A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.html. Contact: slevin@@@aecom.yu.edu; bsatir@@@aecom.yu.edu.

Original languageEnglish (US)
Pages (from-to)374-375
Number of pages2
JournalBioinformatics
Volume14
Issue number4
StatePublished - 1998

Fingerprint

Amino Acid Substitution
Substitution
Amino Acids
Amino acids
Substitution reactions
Proteins
Protein
Evaluation
Sequence Alignment
Protein Sequence
World Wide Web
Conservation
Computer program listings
Alignment
Software
Availability
Contact

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

POLINA : Detection and evaluation of single amino acid substitutions in protein superfamilies. / Levin, Sergei; Satir, Birgit H.

In: Bioinformatics, Vol. 14, No. 4, 1998, p. 374-375.

Research output: Contribution to journalArticle

@article{5ae5deaf6c24448f8463e298f89defc8,
title = "POLINA: Detection and evaluation of single amino acid substitutions in protein superfamilies",
abstract = "Motivation and results: An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program. Availability: A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.html. Contact: slevin@@@aecom.yu.edu; bsatir@@@aecom.yu.edu.",
author = "Sergei Levin and Satir, {Birgit H.}",
year = "1998",
language = "English (US)",
volume = "14",
pages = "374--375",
journal = "Bioinformatics",
issn = "1367-4803",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - POLINA

T2 - Detection and evaluation of single amino acid substitutions in protein superfamilies

AU - Levin, Sergei

AU - Satir, Birgit H.

PY - 1998

Y1 - 1998

N2 - Motivation and results: An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program. Availability: A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.html. Contact: slevin@@@aecom.yu.edu; bsatir@@@aecom.yu.edu.

AB - Motivation and results: An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program. Availability: A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.html. Contact: slevin@@@aecom.yu.edu; bsatir@@@aecom.yu.edu.

UR - http://www.scopus.com/inward/record.url?scp=0031873189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031873189&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 374

EP - 375

JO - Bioinformatics

JF - Bioinformatics

SN - 1367-4803

IS - 4

ER -