POLINA: Detection and evaluation of single amino acid substitutions in protein superfamilies

Sergei Levin, Birgit H. Satir

Research output: Contribution to journalArticle

10 Scopus citations


Motivation and results: An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program. Availability: A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.html. Contact: slevin@@@aecom.yu.edu; bsatir@@@aecom.yu.edu.

Original languageEnglish (US)
Pages (from-to)374-375
Number of pages2
Issue number4
Publication statusPublished - Jan 1 1998


ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

Cite this