@article{ea421ecc4ed4464d885a5f419df7ec56,
title = "PncA gene mutations associated with pyrazinamide resistance in drug-resistant Tuberculosis, South Africa and Georgia",
abstract = "Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drugresistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drugresistant tuberculosis.",
author = "Salim Allana and Elena Shashkina and Barun Mathema and Nino Bablishvili and Nestani Tukvadze and Shah, {N. Sarita} and Kempker, {Russell R.} and Blumberg, {Henry M.} and Pravi Moodley and Koleka Mlisana and Brust, {James C.M.} and Gandhi, {Neel R.}",
note = "Funding Information: This study was funded by grants from the USNational Institutes of Health: R01AI089349 (N.R.G.), R01AI087465 (N.R.G.), K23AI103044 (R.R.K.), and D43TW007124 (H.M.B.). The study also received support in part from the following National Institutes of Health grants: K23AI083088 (J.C.M.B.), K24AI114444 (N.R.G.), Emory Center for AIDS Research P30AI050409, Einstein/Montefiore Institute for Clinical and Translational Research UL1 TR001073, and Atlanta Clinical and Translational Science Institute UL1TR000454. Dr. Allana is assistant director of the Emory TB/HIV Research Group at the Emory Rollins School of Public Health in Atlanta. His primary research interest is the intersection of the drugresistant TB and HIV epidemics in South Africa. Publisher Copyright: {\textcopyright} 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.",
year = "2017",
month = mar,
doi = "10.3201/eid2303.161034",
language = "English (US)",
volume = "23",
pages = "491--495",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "3",
}
