Platelet-associated igg in pediatric HIV infection

Maadhava Ellaurie, Edward R. Burns, Arye Rubinstein

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Hematologic abnormalities, including thrombocytopenia, are seen in HIV infection. Mi have previously reported elevated platelet-associated IgG (PAIgG) in thrombocytopenia in children associated with human immunodeficiency virus (HIV). In this study we prospectively monitored 40 HIV-infected infants and children to determine the significance of elevated PAIgG levels as they relate to thrombocytopenia. We also examined platelet eluatesfor the presence of HIV antibody and antigen. Of 16 patients with thrombocytopenia, 15 (93.7% had elevated PAIgG. Of 24 patients with normal platelet counts, 21 (87.5% had elevated PAIgG. On follow-up, none of the children with normal platelet counts and elevated PAIgG levels developed thrombocytopenia. Examination of the platelet eluates was negative for HIV antibody or P24 antigen. Although the sensitivity of an elevated PAIgG level in predicting thrombocytopenia is 93% its specificity is only 13% Elevated PAIgG levels are therefore not causally related to the development of thrombocytopenia in children.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalPediatric Hematology and Oncology
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1991

Keywords

  • HIV infection
  • Hematologic abnormalities
  • Platelet-associated IgG
  • Thrombocytopenia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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