Platelet-associated igg in pediatric HIV infection

Maadhava Ellaurie, Edward R. Burns, Arye Rubinstein

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hematologic abnormalities, including thrombocytopenia, are seen in HIV infection. Mi have previously reported elevated platelet-associated IgG (PAIgG) in thrombocytopenia in children associated with human immunodeficiency virus (HIV). In this study we prospectively monitored 40 HIV-infected infants and children to determine the significance of elevated PAIgG levels as they relate to thrombocytopenia. We also examined platelet eluatesfor the presence of HIV antibody and antigen. Of 16 patients with thrombocytopenia, 15 (93.7% had elevated PAIgG. Of 24 patients with normal platelet counts, 21 (87.5% had elevated PAIgG. On follow-up, none of the children with normal platelet counts and elevated PAIgG levels developed thrombocytopenia. Examination of the platelet eluates was negative for HIV antibody or P24 antigen. Although the sensitivity of an elevated PAIgG level in predicting thrombocytopenia is 93% its specificity is only 13% Elevated PAIgG levels are therefore not causally related to the development of thrombocytopenia in children.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalPediatric Hematology and Oncology
Volume8
Issue number2
DOIs
StatePublished - 1991

Fingerprint

Pediatrics
Virus Diseases
Platelets
Viruses
Blood Platelets
Thrombocytopenia
HIV
Immunoglobulin G
Platelet Count
Antigens
Antibodies

Keywords

  • Hematologic abnormalities
  • HIV infection
  • Platelet-associated IgG
  • Thrombocytopenia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research
  • Management of Technology and Innovation

Cite this

Platelet-associated igg in pediatric HIV infection. / Ellaurie, Maadhava; Burns, Edward R.; Rubinstein, Arye.

In: Pediatric Hematology and Oncology, Vol. 8, No. 2, 1991, p. 179-185.

Research output: Contribution to journalArticle

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abstract = "Hematologic abnormalities, including thrombocytopenia, are seen in HIV infection. Mi have previously reported elevated platelet-associated IgG (PAIgG) in thrombocytopenia in children associated with human immunodeficiency virus (HIV). In this study we prospectively monitored 40 HIV-infected infants and children to determine the significance of elevated PAIgG levels as they relate to thrombocytopenia. We also examined platelet eluatesfor the presence of HIV antibody and antigen. Of 16 patients with thrombocytopenia, 15 (93.7{\%} had elevated PAIgG. Of 24 patients with normal platelet counts, 21 (87.5{\%} had elevated PAIgG. On follow-up, none of the children with normal platelet counts and elevated PAIgG levels developed thrombocytopenia. Examination of the platelet eluates was negative for HIV antibody or P24 antigen. Although the sensitivity of an elevated PAIgG level in predicting thrombocytopenia is 93{\%} its specificity is only 13{\%} Elevated PAIgG levels are therefore not causally related to the development of thrombocytopenia in children.",
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