Platelet-activating factor contributes to bacillus anthracis lethal toxin-associated damage

Johanna Rivera; Rani S. Sellers; Wangyong Zeng; Nico Van Rooijen; Arturo Casadevall; David L. Goldman

doi:10.1074/jbc.M113.524900

Platelet-activating factor contributes to bacillus anthracis lethal toxin-associated damage

Johanna Rivera, Rani S. Sellers, Wangyong Zeng, Nico Van Rooijen, Arturo Casadevall, David L. Goldman

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: PAF has been implicated as a potent lipid mediator of endotoxin-induced sepsis, but its role in anthraxassociated shock is unknown. Results: Increased serum levels of PAF were present in LeTx-challenged mice. Inhibition of PAF activity prolonged survival ameliorated increased vascular permeability and hepatic necrosis. Conclusion: PAF appears to be a mediator in lethal toxin-associated damage. Significance: PAF antagonists may be helpful as adjunctive therapy for anthrax-associated shock.

Original language	English (US)
Pages (from-to)	7131-7141
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M113.524900
State	Published - Mar 7 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Platelet-activating factor contributes to bacillus anthracis lethal toxin-associated damage",

abstract = "Background: PAF has been implicated as a potent lipid mediator of endotoxin-induced sepsis, but its role in anthraxassociated shock is unknown. Results: Increased serum levels of PAF were present in LeTx-challenged mice. Inhibition of PAF activity prolonged survival ameliorated increased vascular permeability and hepatic necrosis. Conclusion: PAF appears to be a mediator in lethal toxin-associated damage. Significance: PAF antagonists may be helpful as adjunctive therapy for anthrax-associated shock.",

author = "Johanna Rivera and Sellers, {Rani S.} and Wangyong Zeng and {Van Rooijen}, Nico and Arturo Casadevall and Goldman, {David L.}",

year = "2014",

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doi = "10.1074/jbc.M113.524900",

language = "English (US)",

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T1 - Platelet-activating factor contributes to bacillus anthracis lethal toxin-associated damage

AU - Rivera, Johanna

AU - Sellers, Rani S.

AU - Zeng, Wangyong

AU - Van Rooijen, Nico

AU - Casadevall, Arturo

AU - Goldman, David L.

PY - 2014/3/7

Y1 - 2014/3/7

N2 - Background: PAF has been implicated as a potent lipid mediator of endotoxin-induced sepsis, but its role in anthraxassociated shock is unknown. Results: Increased serum levels of PAF were present in LeTx-challenged mice. Inhibition of PAF activity prolonged survival ameliorated increased vascular permeability and hepatic necrosis. Conclusion: PAF appears to be a mediator in lethal toxin-associated damage. Significance: PAF antagonists may be helpful as adjunctive therapy for anthrax-associated shock.

AB - Background: PAF has been implicated as a potent lipid mediator of endotoxin-induced sepsis, but its role in anthraxassociated shock is unknown. Results: Increased serum levels of PAF were present in LeTx-challenged mice. Inhibition of PAF activity prolonged survival ameliorated increased vascular permeability and hepatic necrosis. Conclusion: PAF appears to be a mediator in lethal toxin-associated damage. Significance: PAF antagonists may be helpful as adjunctive therapy for anthrax-associated shock.

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SP - 7131

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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Platelet-activating factor contributes to bacillus anthracis lethal toxin-associated damage

Abstract

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