Plasmodium falciparum: Inhibition of in vitro growth by desferrioxamine

C. Raventos-Suarez, Simeon Pollack, R. L. Nagel

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Infectious agents must acquire iron from their host to survive, and iron deficiency has been reported to protect against malaria in humans. We have tested the susceptibility of Plasmodium falciparum to iron deprivation by studying the effect of desferrioxamine (DF), a specific iron chelating agent, on parasite growth in an in vitro culture system. We have found that DF inhibits the growth of P. falciparum at concentrations readily achievable in vivo, by a mechanism that may involve interference with the completion of schizogony.

Original languageEnglish (US)
Pages (from-to)919-922
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume31
Issue number5
StatePublished - 1982

Fingerprint

Deferoxamine
Plasmodium falciparum
Iron
Growth
Iron Chelating Agents
Malaria
Parasites
In Vitro Techniques

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Plasmodium falciparum : Inhibition of in vitro growth by desferrioxamine. / Raventos-Suarez, C.; Pollack, Simeon; Nagel, R. L.

In: American Journal of Tropical Medicine and Hygiene, Vol. 31, No. 5, 1982, p. 919-922.

Research output: Contribution to journalArticle

Raventos-Suarez, C, Pollack, S & Nagel, RL 1982, 'Plasmodium falciparum: Inhibition of in vitro growth by desferrioxamine', American Journal of Tropical Medicine and Hygiene, vol. 31, no. 5, pp. 919-922.
Raventos-Suarez, C. ; Pollack, Simeon ; Nagel, R. L. / Plasmodium falciparum : Inhibition of in vitro growth by desferrioxamine. In: American Journal of Tropical Medicine and Hygiene. 1982 ; Vol. 31, No. 5. pp. 919-922.
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