TY - JOUR
T1 - Plasmodium falciparum
T2 - Inhibition of in vitro growth by desferrioxamine
AU - Raventos-Suarez, C.
AU - Pollack, S.
AU - Nagel, R. L.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1982
Y1 - 1982
N2 - Infectious agents must acquire iron from their host to survive, and iron deficiency has been reported to protect against malaria in humans. We have tested the susceptibility of Plasmodium falciparum to iron deprivation by studying the effect of desferrioxamine (DF), a specific iron chelating agent, on parasite growth in an in vitro culture system. We have found that DF inhibits the growth of P. falciparum at concentrations readily achievable in vivo, by a mechanism that may involve interference with the completion of schizogony.
AB - Infectious agents must acquire iron from their host to survive, and iron deficiency has been reported to protect against malaria in humans. We have tested the susceptibility of Plasmodium falciparum to iron deprivation by studying the effect of desferrioxamine (DF), a specific iron chelating agent, on parasite growth in an in vitro culture system. We have found that DF inhibits the growth of P. falciparum at concentrations readily achievable in vivo, by a mechanism that may involve interference with the completion of schizogony.
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U2 - 10.4269/ajtmh.1982.31.919
DO - 10.4269/ajtmh.1982.31.919
M3 - Article
C2 - 6751113
AN - SCOPUS:0019948542
SN - 0002-9637
VL - 31
SP - 919
EP - 922
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -
