Plasmodium falciparum infection does not affect human immunodeficiency virus viral load in coinfected Rwandan adults

Krishanthi Subramaniam, Rebeca M. Plank, Nina Lin, Adam Goldman-Yassen, Emil Ivan, Carlos Becerril, Kimdar Kemal, Moonseong Heo, Marla J. Keller, Eugene Mutimura, Kathryn Anastos, Johanna P. Daily

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background. Plasmodium falciparum infection has been reported to increase human immunodeficiency virus (HIV) viral load (VL), which can facilitate HIV transmission. We prospectively studied the impact of mild P falciparum coinfection on HIV VL in Rwanda. Methods. We measured plasma HIV VL at presentation with malaria infection and weekly for 4 weeks after artemether-lumefantrine treatment in Rwandan adults infected with HIV with P falciparum malaria. Regression analyses were used to examine associations between malaria infection and HIV VL changes. Samples with detectable virus underwent genotypic drug-resistance testing. Results. We enrolled 28 HIV-malaria coinfected patients and observed 27 of them for 5 weeks. Three patients (11%) were newly diagnosed with HIV. Acute P falciparum infection had no significant effect on HIV VL slope over 28 days of follow-up. Ten patients with VL

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume1
Issue number2
DOIs
StatePublished - 2014

Keywords

  • Antiretroviral drug resistance
  • HIV
  • Malaria
  • Plasmodium falciparum
  • Rwanda

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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