Plasmodium falciparum infection does not affect human immunodeficiency virus viral load in coinfected Rwandan adults

Krishanthi Subramaniam, Rebeca M. Plank, Nina Lin, Adam Goldman-Yassen, Emil Ivan, Carlos Becerril, Kimdar Kemal, Moonseong Heo, Marla J. Keller, Eugene Mutimura, Kathryn Anastos, Johanna P. Daily

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2 Scopus citations


Background. Plasmodium falciparum infection has been reported to increase human immunodeficiency virus (HIV) viral load (VL), which can facilitate HIV transmission. We prospectively studied the impact of mild P falciparum coinfection on HIV VL in Rwanda. Methods. We measured plasma HIV VL at presentation with malaria infection and weekly for 4 weeks after artemether-lumefantrine treatment in Rwandan adults infected with HIV with P falciparum malaria. Regression analyses were used to examine associations between malaria infection and HIV VL changes. Samples with detectable virus underwent genotypic drug-resistance testing. Results. We enrolled 28 HIV-malaria coinfected patients and observed 27 of them for 5 weeks. Three patients (11%) were newly diagnosed with HIV. Acute P falciparum infection had no significant effect on HIV VL slope over 28 days of follow-up. Ten patients with VL

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Issue number2
StatePublished - 2014



  • Antiretroviral drug resistance
  • HIV
  • Malaria
  • Plasmodium falciparum
  • Rwanda

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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