Plasmodium falciparum biology: analysis of in vitro versus in vivo growth conditions

Michele LeRoux, Viswanathan Lakshmanan, Johanna P. Daily

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Recent studies of Plasmodium falciparum isolated directly from infected patients indicate that alternative parasite biological states occur in the natural host that are not observed with in vitro cultivated parasites. Variation in host substrates, immune responses and other factors probably induce modifications in parasite biology. These biological states could have important implications for pathogenesis, transmission and therapy. We review the differences between P. falciparum in vitro culture systems and in vivo host environments, as well as evidence that host conditions can alter pathogen biology. For select biological questions, the incorporation of naturally occurring conditions into in vitro experimental manipulation of microbes may provide novel insight into pathogen biology.

Original languageEnglish (US)
Pages (from-to)474-481
Number of pages8
JournalTrends in Parasitology
Volume25
Issue number10
DOIs
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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