Plasma vitamin C and uterine cervical dysplasia

Seymour L. Romney, Chandralekha Duttagupta, Jayasri Basu, Prabhudas R. Palan, Stewart Karp, N. Susan Slagle, Annette Dwyer, Sylvia Wassertheil-Smoller, Judith Wylie-Rosett

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46 Scopus citations


Plasma concentrations of vitamin C were determined in a case-control study of women (n = 80) who had sought a Papanicolaou test in the Bronx Municipal Hospital Center, Controls (n = 34) were women having negative cytologic tests, negative colposcopic findings, and no known gynecologic dysfunction. Cases (n = 46) were defined as women who had either one positive or two consecutive suspicious Papanicolaou smears in a 12-month period. The mean concentration of vitamin C in the plasma was significantly lower in the cases than in the controls (0.36 versus 0.75 mg/dl, p < 0.0001). Cases were further stratified according to the histopathologic diagnosis. The data direct attention to a possible etiologic association of vitamin C in human cervical epithelial abnormalities. A clinical trial with vitamin C intervention is suggested.

Original languageEnglish (US)
Pages (from-to)976-980
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number7
StatePublished - Apr 1 1985


  • Cervical dysplasia
  • colposcopy
  • cytology
  • plasma vitamin C

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Romney, S. L., Duttagupta, C., Basu, J., Palan, P. R., Karp, S., Slagle, N. S., Dwyer, A., Wassertheil-Smoller, S., & Wylie-Rosett, J. (1985). Plasma vitamin C and uterine cervical dysplasia. American Journal of Obstetrics and Gynecology, 151(7), 976-980.