Plasma vitamin C and uterine cervical dysplasia

Seymour L. Romney, Chandralekha Duttagupta, Jayasri Basu, Prabhudas R. Palan, Stewart Karp, N. Susan Slagle, Annette Dwyer, Sylvia Wassertheil-Smoller, Judith Wylie-Rosett

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Plasma concentrations of vitamin C were determined in a case-control study of women (n = 80) who had sought a Papanicolaou test in the Bronx Municipal Hospital Center, Controls (n = 34) were women having negative cytologic tests, negative colposcopic findings, and no known gynecologic dysfunction. Cases (n = 46) were defined as women who had either one positive or two consecutive suspicious Papanicolaou smears in a 12-month period. The mean concentration of vitamin C in the plasma was significantly lower in the cases than in the controls (0.36 versus 0.75 mg/dl, p < 0.0001). Cases were further stratified according to the histopathologic diagnosis. The data direct attention to a possible etiologic association of vitamin C in human cervical epithelial abnormalities. A clinical trial with vitamin C intervention is suggested.

Original languageEnglish (US)
Pages (from-to)976-980
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume151
Issue number7
DOIs
StatePublished - Apr 1 1985

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Uterine Cervical Dysplasia
Ascorbic Acid
Papanicolaou Test
Municipal Hospitals
Case-Control Studies
Clinical Trials

Keywords

  • Cervical dysplasia
  • colposcopy
  • cytology
  • plasma vitamin C

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Romney, S. L., Duttagupta, C., Basu, J., Palan, P. R., Karp, S., Slagle, N. S., ... Wylie-Rosett, J. (1985). Plasma vitamin C and uterine cervical dysplasia. American Journal of Obstetrics and Gynecology, 151(7), 976-980. https://doi.org/10.1016/0002-9378(85)90677-5

Plasma vitamin C and uterine cervical dysplasia. / Romney, Seymour L.; Duttagupta, Chandralekha; Basu, Jayasri; Palan, Prabhudas R.; Karp, Stewart; Slagle, N. Susan; Dwyer, Annette; Wassertheil-Smoller, Sylvia; Wylie-Rosett, Judith.

In: American Journal of Obstetrics and Gynecology, Vol. 151, No. 7, 01.04.1985, p. 976-980.

Research output: Contribution to journalArticle

Romney, SL, Duttagupta, C, Basu, J, Palan, PR, Karp, S, Slagle, NS, Dwyer, A, Wassertheil-Smoller, S & Wylie-Rosett, J 1985, 'Plasma vitamin C and uterine cervical dysplasia', American Journal of Obstetrics and Gynecology, vol. 151, no. 7, pp. 976-980. https://doi.org/10.1016/0002-9378(85)90677-5
Romney SL, Duttagupta C, Basu J, Palan PR, Karp S, Slagle NS et al. Plasma vitamin C and uterine cervical dysplasia. American Journal of Obstetrics and Gynecology. 1985 Apr 1;151(7):976-980. https://doi.org/10.1016/0002-9378(85)90677-5
Romney, Seymour L. ; Duttagupta, Chandralekha ; Basu, Jayasri ; Palan, Prabhudas R. ; Karp, Stewart ; Slagle, N. Susan ; Dwyer, Annette ; Wassertheil-Smoller, Sylvia ; Wylie-Rosett, Judith. / Plasma vitamin C and uterine cervical dysplasia. In: American Journal of Obstetrics and Gynecology. 1985 ; Vol. 151, No. 7. pp. 976-980.
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