TY - JOUR
T1 - Plasma uric acid levels in women with cervical intraepithelial neoplasia
AU - Basu, Jayasri
AU - Mikhail, Magdy S.
AU - Ahn, Chul W.
AU - Furguiele, Joseph
AU - Ho, Gloria Y.
AU - Burk, Robert D.
AU - Palan, Prabhudas R.
AU - Romney, Seymour L.
N1 - Funding Information:
The study is supported by the Friends of Gynecologic Cancer Research of the Albert Einstein College of Medicine. The authors thank Dr. C. Duttagupta for critically reading the manuscript and for her comments, Mary Sarvendeker for interviewing and recruiting patients and in retrieving patients’ clinical reports, Andrew Fusina and Leslie Snyder for their technical assistance, and the support of the Service Engineers of the Water Associates, Milford, Massachusetts. Address correspondence to Dr. J. Basu, Albert Einstein College of Medicine, Dept. of Molecular Pharmacology, Forchheimer Building, Room 219, Bronx, NY 10461. Phone (718) 430–2614, Fax: (718) 430–8992. E-mail:jbasu@aecom.yu.edu.
PY - 2005
Y1 - 2005
N2 - The objective of this study was to determine the association of plasma levels of uric acid, an endogenous antioxidant, in women with cervical intraepithelial neoplasia (CIN), while controlling for the confounding effects of human papillomavirus (HPV) infection, age, smoking, and use of oral contraception. Plasma-reduced and oxidized uric acid levels were determined in 650 women by high-performance liquid chromatography, employing electrochemical technique. The findings demonstrated that 1) plasma-reduced uric acid (PRUA) levels in women with CIN (n = 311) were significantly lower (P < 0.05) compared with women in a control group (n = 339); 2) according to multiple logistic regression analysis, PRUA levels were negatively (P = 0.0113) and HPV infection were positively associated (P < 0.0001) with CIN, after controlling for the confounding effects of the studied factors; 3) according to multiple regression analysis, there was a 31% decrease in CIN risk for each incremental increase of 1mg/dl of PRUA; and 4) according to polychotomous logistic regression analysis, independent of HPV infection, PRUA level was inversely associated with the histopathological graded severity of CIN. We have previously reported decreased plasma levels of exogenous antioxidants, for example, vitamins C and E, in women with CIN independent of HPV infection. The data suggest that plasma deficiencies of several antioxidants in HPV-infected uterine cervical tissue may create an oxidative environment that renders the tissue susceptible to free radical damage. It may be speculated that chronic free radical-induced tissue damage in the context of persistent HPV infection may be involved in the pathogenesis of CIN.
AB - The objective of this study was to determine the association of plasma levels of uric acid, an endogenous antioxidant, in women with cervical intraepithelial neoplasia (CIN), while controlling for the confounding effects of human papillomavirus (HPV) infection, age, smoking, and use of oral contraception. Plasma-reduced and oxidized uric acid levels were determined in 650 women by high-performance liquid chromatography, employing electrochemical technique. The findings demonstrated that 1) plasma-reduced uric acid (PRUA) levels in women with CIN (n = 311) were significantly lower (P < 0.05) compared with women in a control group (n = 339); 2) according to multiple logistic regression analysis, PRUA levels were negatively (P = 0.0113) and HPV infection were positively associated (P < 0.0001) with CIN, after controlling for the confounding effects of the studied factors; 3) according to multiple regression analysis, there was a 31% decrease in CIN risk for each incremental increase of 1mg/dl of PRUA; and 4) according to polychotomous logistic regression analysis, independent of HPV infection, PRUA level was inversely associated with the histopathological graded severity of CIN. We have previously reported decreased plasma levels of exogenous antioxidants, for example, vitamins C and E, in women with CIN independent of HPV infection. The data suggest that plasma deficiencies of several antioxidants in HPV-infected uterine cervical tissue may create an oxidative environment that renders the tissue susceptible to free radical damage. It may be speculated that chronic free radical-induced tissue damage in the context of persistent HPV infection may be involved in the pathogenesis of CIN.
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U2 - 10.1207/s15327914nc5101_4
DO - 10.1207/s15327914nc5101_4
M3 - Article
C2 - 15749626
AN - SCOPUS:14944360618
SN - 0163-5581
VL - 51
SP - 25
EP - 31
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 1
ER -