Plasma uric acid levels in women with cervical intraepithelial neoplasia

Jayasri Basu, Magdy S. Mikhail, Chul W. Ahn, Joseph Furguiele, Gloria Y. Ho, Robert D. Burk, Prabhudas R. Palan, Seymour L. Romney

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The objective of this study was to determine the association of plasma levels of uric acid, an endogenous antioxidant, in women with cervical intraepithelial neoplasia (CIN), while controlling for the confounding effects of human papillomavirus (HPV) infection, age, smoking, and use of oral contraception. Plasma-reduced and oxidized uric acid levels were determined in 650 women by high-performance liquid chromatography, employing electrochemical technique. The findings demonstrated that 1) plasma-reduced uric acid (PRUA) levels in women with CIN (n = 311) were significantly lower (P < 0.05) compared with women in a control group (n = 339); 2) according to multiple logistic regression analysis, PRUA levels were negatively (P = 0.0113) and HPV infection were positively associated (P < 0.0001) with CIN, after controlling for the confounding effects of the studied factors; 3) according to multiple regression analysis, there was a 31% decrease in CIN risk for each incremental increase of 1mg/dl of PRUA; and 4) according to polychotomous logistic regression analysis, independent of HPV infection, PRUA level was inversely associated with the histopathological graded severity of CIN. We have previously reported decreased plasma levels of exogenous antioxidants, for example, vitamins C and E, in women with CIN independent of HPV infection. The data suggest that plasma deficiencies of several antioxidants in HPV-infected uterine cervical tissue may create an oxidative environment that renders the tissue susceptible to free radical damage. It may be speculated that chronic free radical-induced tissue damage in the context of persistent HPV infection may be involved in the pathogenesis of CIN.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalNutrition and Cancer
Volume51
Issue number1
DOIs
StatePublished - 2005

Fingerprint

Cervical Intraepithelial Neoplasia
uric acid
Uric Acid
Papillomaviridae
Papillomavirus Infections
neoplasms
regression analysis
infection
Antioxidants
antioxidants
Regression Analysis
Free Radicals
Logistic Models
Electrochemical Techniques
contraception
vitamin E
Vitamin E
Contraception
mouth
Ascorbic Acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Food Science

Cite this

Basu, J., Mikhail, M. S., Ahn, C. W., Furguiele, J., Ho, G. Y., Burk, R. D., ... Romney, S. L. (2005). Plasma uric acid levels in women with cervical intraepithelial neoplasia. Nutrition and Cancer, 51(1), 25-31. https://doi.org/10.1207/s15327914nc5101_4

Plasma uric acid levels in women with cervical intraepithelial neoplasia. / Basu, Jayasri; Mikhail, Magdy S.; Ahn, Chul W.; Furguiele, Joseph; Ho, Gloria Y.; Burk, Robert D.; Palan, Prabhudas R.; Romney, Seymour L.

In: Nutrition and Cancer, Vol. 51, No. 1, 2005, p. 25-31.

Research output: Contribution to journalArticle

Basu, J, Mikhail, MS, Ahn, CW, Furguiele, J, Ho, GY, Burk, RD, Palan, PR & Romney, SL 2005, 'Plasma uric acid levels in women with cervical intraepithelial neoplasia', Nutrition and Cancer, vol. 51, no. 1, pp. 25-31. https://doi.org/10.1207/s15327914nc5101_4
Basu, Jayasri ; Mikhail, Magdy S. ; Ahn, Chul W. ; Furguiele, Joseph ; Ho, Gloria Y. ; Burk, Robert D. ; Palan, Prabhudas R. ; Romney, Seymour L. / Plasma uric acid levels in women with cervical intraepithelial neoplasia. In: Nutrition and Cancer. 2005 ; Vol. 51, No. 1. pp. 25-31.
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