Plasma R Binder Deficiency and Neurologic Disease

Samuel Harold Sigal, Charles A. Hall, Jack P. Antel

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


THE extracellular transport of vitamin B12 (cobalamin) is complicated and incompletely understood. Transport in plasma is associated with two carriers: transcobalamin II and R binder protein (R denotes “rapid” and refers to electrophoretic mobility).1 Transcobalamin II is required for efficient cellular uptake of cobalamin; in the rare cases of newborns with congenital deficiency of the protein, intractable megaloblastic anemia develops and is responsive only to pharmacologic doses of the vitamin.2 R binder proteins are a class of immunologically identical but electrophoretically distinct glycoproteins with molecular weights of 56,000 to 62,000. They are found in many secretions and differ only.

Original languageEnglish (US)
Pages (from-to)1330-1332
Number of pages3
JournalNew England Journal of Medicine
Issue number21
StatePublished - Nov 19 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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