TY - JOUR
T1 - Plasma R Binder Deficiency and Neurologic Disease
AU - Sigal, Samuel Harold
AU - Hall, Charles A.
AU - Antel, Jack P.
PY - 1987/11/19
Y1 - 1987/11/19
N2 - THE extracellular transport of vitamin B12 (cobalamin) is complicated and incompletely understood. Transport in plasma is associated with two carriers: transcobalamin II and R binder protein (R denotes “rapid” and refers to electrophoretic mobility).1 Transcobalamin II is required for efficient cellular uptake of cobalamin; in the rare cases of newborns with congenital deficiency of the protein, intractable megaloblastic anemia develops and is responsive only to pharmacologic doses of the vitamin.2 R binder proteins are a class of immunologically identical but electrophoretically distinct glycoproteins with molecular weights of 56,000 to 62,000. They are found in many secretions and differ only.
AB - THE extracellular transport of vitamin B12 (cobalamin) is complicated and incompletely understood. Transport in plasma is associated with two carriers: transcobalamin II and R binder protein (R denotes “rapid” and refers to electrophoretic mobility).1 Transcobalamin II is required for efficient cellular uptake of cobalamin; in the rare cases of newborns with congenital deficiency of the protein, intractable megaloblastic anemia develops and is responsive only to pharmacologic doses of the vitamin.2 R binder proteins are a class of immunologically identical but electrophoretically distinct glycoproteins with molecular weights of 56,000 to 62,000. They are found in many secretions and differ only.
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U2 - 10.1056/NEJM198711193172106
DO - 10.1056/NEJM198711193172106
M3 - Article
C2 - 3683461
AN - SCOPUS:0023253182
SN - 0028-4793
VL - 317
SP - 1330
EP - 1332
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -