@article{5f0c4182d33d4864878ee6504aa5129f,
title = "Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition",
abstract = "Introduction: We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations. Methods: We tested metabolite-cognitive function associations in U.S.A. Hispanic/Latino adults (n = 2222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European (n = 1365) and African (n = 478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function. Results: Six metabolites were consistently associated with lower global cognitive function across all studies. Of these, four were sugar-related (e.g., ribitol). MR analyses provided weak evidence for a potential causal effect of ribitol on cognitive function and bi-directional effects of cognitive performance on diet. Discussion: Several diet-related metabolites were associated with global cognitive function across studies with different race/ethnicities. Highlights: Metabolites associated with cognitive function in Puerto Rican adults were recently identified. We demonstrate the generalizability of these associations across diverse race/ethnicities. Most identified metabolites are related to sugars. Mendelian Randomization (MR) provides weak evidence for a causal effect of ribitol on cognitive function. Beta-cryptoxanthin and other metabolites highlight the importance of a healthy diet.",
keywords = "Global cognitive function, Mediterranean diet, Metabolites, Puerto Rican, Race/ethnicities, U.S. Hispanics/Latinos",
author = "Einat Granot-Hershkovitz and Shan He and Jan Bressler and Bing Yu and Wassim Tarraf and Rebholz, {Casey M.} and Jianwen Cai and Queenie Chan and Garcia, {Tanya P.} and Thomas Mosley and Kristal, {Bruce S.} and Charles DeCarli and Myriam Fornage and Chen, {Guo Chong} and Qibin Qi and Robert Kaplan and Gonz{\'a}lez, {Hector M.} and Tamar Sofer",
note = "Funding Information: The authors thank the staff and participants of HCHS/SOL for their important contributions. Investigators{\textquoteright} website – https://sites.cscc.unc.edu/hchs/ . The Hispanic Community Health Study/Study of Latinos is a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (HHSN268201300001I/N01‐HC‐65233), University of Miami (HHSN268201300004I/N01‐HC‐65234), Albert Einstein College of Medicine (HHSN268201300002I/N01‐HC‐65235), University of Illinois at Chicago (HHSN268201300003I/N01‐ HC‐65236 Northwestern Univ), and San Diego State University (HHSN268201300005I/N01‐HC‐65237). The following Institutes/Centers/Offices have contributed to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution‐Office of Dietary Supplements. This work was supported by the National Institute on Aging (R21AG070644, R01AG048642, RF1AG054548, RF1AG061022, and R21AG056952). Dr. Gonz{\'a}lez also receives additional support from P30AG062429 and P30AG059299. Support for metabolomics data was graciously provided by the JLH Foundation (Houston, Texas). The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services under contract numbers (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, and HHSN268201700005I). The authors thank the staff and participants of the ARIC study for their important contributions. The metabolomics research was sponsored by the National Human Genome Research Institute (3U01HG004402‐02S1). Publisher Copyright: {\textcopyright} 2022 the Alzheimer's Association.",
year = "2022",
doi = "10.1002/alz.12786",
language = "English (US)",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
}
