TY - JOUR
T1 - Plasma matrix metalloproteinase and tissue inhibitor of metalloproteinase in patients with agnogenic myeloid metaplasia or idiopathic primary myelofibrosis
AU - Wang, Jen C.
AU - Novetsky, Akiva
AU - Chen, Chi
AU - Novetsky, Allan D.
PY - 2002
Y1 - 2002
N2 - Agnogenic myeloid metaplasia (AMM) is characterized by bone marrow fibrosis with abnormal accumulation of extracellular matrix components (ECM), which is dependent on the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Twenty-five patients with AMM, 30 with essential thrombocythemia (ET), 12 with polycythemia vera (PV) and 20 normal control subjects were studied. AMM patients had decreased plasma levels of MMP-3 and marked elevated levels of TIMP-1, but MMP-1, MMP-2 and MMP-9 levels were not significantly different from control subjects. Elevated levels of plasma TIMP-1, but not MMPs, were found in ET and PV. Reduced MMP activity together with increased TIMP-1 activity may be essential in fibrosis formation.
AB - Agnogenic myeloid metaplasia (AMM) is characterized by bone marrow fibrosis with abnormal accumulation of extracellular matrix components (ECM), which is dependent on the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Twenty-five patients with AMM, 30 with essential thrombocythemia (ET), 12 with polycythemia vera (PV) and 20 normal control subjects were studied. AMM patients had decreased plasma levels of MMP-3 and marked elevated levels of TIMP-1, but MMP-1, MMP-2 and MMP-9 levels were not significantly different from control subjects. Elevated levels of plasma TIMP-1, but not MMPs, were found in ET and PV. Reduced MMP activity together with increased TIMP-1 activity may be essential in fibrosis formation.
KW - Agnogenic myeloid metaplasia
KW - Idiopathic primary myelofibrosis
KW - Matrix metalloproteinase
KW - Tissue inhibitor of metalloproteinase
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U2 - 10.1046/j.1365-2141.2002.03874.x
DO - 10.1046/j.1365-2141.2002.03874.x
M3 - Article
C2 - 12437648
AN - SCOPUS:0036436308
SN - 0007-1048
VL - 119
SP - 709
EP - 712
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 3
ER -