Plasma free fatty acids and risk of atrial fibrillation (from the Cardiovascular Health Study)

Owais Khawaja, Traci M. Bartz, Joachim H. Ix, Susan R. Heckbert, Jorge Kizer, Susan J. Zieman, Kenneth J. Mukamal, Russell P. Tracy, David S. Siscovick, Luc Djoussé

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia in clinical practice, affecting approximately 2.3 million residents of the United States and 4.5 million residents of the European Union. It is unclear whether plasma free fatty acids (FFAs) influence the risk of AF in older adults. The aim of this study was to prospectively examine the association between plasma FFAs and incident AF in a prospective cohort of 4,175 men and women <65 years old from the Cardiovascular Health Study. Plasma concentrations of FFAs were measured 2 times during the 1992 to 1993 examination. Incident AF was ascertained based on study electrocardiographic and hospitalization records during follow-up. We used Cox regression to estimate relative risks of AF. Average age at baseline was 74.6 ± 5.1 years. During a mean follow-up of 10.0 years, 1,041 new cases of AF occurred. Crude incidence rates of AF were 23.7, 23.3, 23.9, and 29.7 cases/1,000 person-years across consecutive quartiles of plasma FFAs. There was a positive association between plasma FFAs and risk of AF. Multivariable adjusted hazard ratios (95% confidence intervals) for incident AF were 1.00 (referent), 1.02 (0.85 to 1.21), 1.05 (0.88 to 1.26), and 1.29 (1.08 to 1.55) from the lowest to highest quartiles of FFAs, respectively. In a secondary analysis restricted to the first 5 years of follow-up, this association persisted. In conclusion, our data show an increased risk of AF with higher plasma FFAs in community-dwelling older adults.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalAmerican Journal of Cardiology
Volume110
Issue number2
DOIs
StatePublished - Jul 15 2012
Externally publishedYes

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Nonesterified Fatty Acids
Atrial Fibrillation
Health
Independent Living
European Union
Cardiac Arrhythmias
Hospitalization
Confidence Intervals
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Plasma free fatty acids and risk of atrial fibrillation (from the Cardiovascular Health Study). / Khawaja, Owais; Bartz, Traci M.; Ix, Joachim H.; Heckbert, Susan R.; Kizer, Jorge; Zieman, Susan J.; Mukamal, Kenneth J.; Tracy, Russell P.; Siscovick, David S.; Djoussé, Luc.

In: American Journal of Cardiology, Vol. 110, No. 2, 15.07.2012, p. 212-216.

Research output: Contribution to journalArticle

Khawaja, O, Bartz, TM, Ix, JH, Heckbert, SR, Kizer, J, Zieman, SJ, Mukamal, KJ, Tracy, RP, Siscovick, DS & Djoussé, L 2012, 'Plasma free fatty acids and risk of atrial fibrillation (from the Cardiovascular Health Study)', American Journal of Cardiology, vol. 110, no. 2, pp. 212-216. https://doi.org/10.1016/j.amjcard.2012.03.010
Khawaja, Owais ; Bartz, Traci M. ; Ix, Joachim H. ; Heckbert, Susan R. ; Kizer, Jorge ; Zieman, Susan J. ; Mukamal, Kenneth J. ; Tracy, Russell P. ; Siscovick, David S. ; Djoussé, Luc. / Plasma free fatty acids and risk of atrial fibrillation (from the Cardiovascular Health Study). In: American Journal of Cardiology. 2012 ; Vol. 110, No. 2. pp. 212-216.
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