Plasma cell leukemia with an unusual karyotype and prolonged survival with oral alkylating agent therapy

P. H. Wiernik, D. Sciortino, Elisabeth M. Paietta, P. Papenhausen, N. Ciobanu, M. Roberts

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A patient with primary plasma cell leukemia (PCL) is presented, who had an excellent response to high-dose cyclophosphamide and prolonged survival. The sole cytogenetic abnormality detected in the bone marrow was monosomy 18. Although this karyotypic aberration has been previously described in PCL, it generally occurs associated with additional abnormalities. The peripheral blood plasma cells from this patient reacted intracellularly with the monoclonal antibody OKM-1, which binds to myeloid cells at and above the level of myelocytes and to monocytes. This finding supports the idea of a common precursor cell for plasma cells and cells of the myelomonocytic lineage.

Original languageEnglish (US)
Pages (from-to)576-578
Number of pages3
JournalJournal of Cancer Research and Clinical Oncology
Volume113
Issue number6
DOIs
StatePublished - Nov 1987

Fingerprint

Plasma Cell Leukemia
Alkylating Agents
Plasma Cells
Karyotype
Monosomy
Granulocyte Precursor Cells
Survival
Cell Lineage
Myeloid Cells
Chromosome Aberrations
Cyclophosphamide
Monocytes
Blood Cells
Bone Marrow
Monoclonal Antibodies
Therapeutics

Keywords

  • Cytogenetics
  • Plasma cell leukemia
  • Response to treatment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Plasma cell leukemia with an unusual karyotype and prolonged survival with oral alkylating agent therapy. / Wiernik, P. H.; Sciortino, D.; Paietta, Elisabeth M.; Papenhausen, P.; Ciobanu, N.; Roberts, M.

In: Journal of Cancer Research and Clinical Oncology, Vol. 113, No. 6, 11.1987, p. 576-578.

Research output: Contribution to journalArticle

Wiernik, P. H. ; Sciortino, D. ; Paietta, Elisabeth M. ; Papenhausen, P. ; Ciobanu, N. ; Roberts, M. / Plasma cell leukemia with an unusual karyotype and prolonged survival with oral alkylating agent therapy. In: Journal of Cancer Research and Clinical Oncology. 1987 ; Vol. 113, No. 6. pp. 576-578.
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