Plasma cell leukemia with an unusual karyotype and prolonged survival following oral alkylating agent therapy

P. H. Wiernik, D. Sciortino, E. Paietta, P. Papenhausen, N. Ciobanu, M. Roberts

Research output: Contribution to journalArticle

2 Scopus citations


A patient with primary plasma cell leukemia (PCL) is presented who had an excellent response to high-dole cyclophosphamide and prolonged survival. The sole cytogenetic abnormality detected in the bone marrow was monosomy 18. Although this karyotypic aberration has been previously described in PCL, it generally occurs associated with additional abnormalities. The peripheral blood plasma cells from this patient reacted intracellularly with the monoclonal antibody OKM-1, which binds to myeloid cells at and above the level of myelocytes and to monocytes. This finding supports a common precursor cell for plasma cells and cells of the myelomonocytic lineage.

Original languageEnglish (US)
Pages (from-to)495-497
Number of pages3
JournalJournal of Cancer Research and Clinical Oncology
Issue number5
StatePublished - Aug 1 1987



  • Cytogenetics
  • Plasma cell leukemia
  • Response to treatment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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