Plasma cell dynamics in the bone marrow niche

Zachary Benet, Zhixin Jing, David R. Fooksman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest. BM PCs accumulate into clusters, which have reduced cell motility. APRIL promotes cluster formation and overall PC motility in the BM. Although CXCL12 and its receptor, CXCR4, promote PC motility in the BM, VLA4 activity promotes arrest. However, blocking either pathway promotes PC egress from the BM. Under steady-state conditions, BM PCs recirculate to other bones and spleen. In older mice, overall PC motility and recirculation increase, and this is correlated with increased CXCR4 expression, which depends on PC age or maturation rather than mouse age. Altogether, these results suggest that changes in PC motility and CXCR4 expression are linked with survival of long-lived PCs in the BM.

Original languageEnglish (US)
Article number108733
JournalCell Reports
Volume34
Issue number6
DOIs
StatePublished - Feb 9 2021

Keywords

  • APRIL
  • CXCL12
  • CXCR4
  • VLA-4
  • antibody secreting cells
  • bone marrow
  • intravital imaging
  • migration
  • plasma cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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