Plasma C-reactive protein levels are associated with improved outcome in ARDS

Ednan K. Bajwa, Uzma A. Khan, James L. Januzzi, Michelle Ng Gong, B. Taylor Thompson, David C. Christiani

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: C-reactive protein (CRP) has been studied as a marker of systemic inflammation and outcome in a number of diseases, but little is known about its characteristics in ARDS. We sought to examine plasma levels of CRP in patients with ARDS and their relationship to outcome and measures of illness severity. Methods: We measured CRP levels in 177 patients within 48 h of disease onset and tested the association of protein level with 60-day mortality, 28-day daily organ dysfunction scores, and number of ventilator-free days. Results: We found that CRP levels were significantly lower in nonsurvivors when compared with survivors (p = 0.02). Mortality rate decreased with increasing CRP decile (p = 0.02). An increasing CRP level was associated with a significantly higher probability of survival at 60 days (p = 0.005). This difference persisted after adjustment for age and severity of illness in a multivariable model (p = 0.009). Multivariable models were also used to show that patients in the group with higher CRP levels had significantly lower organ dysfunction scores (p = 0.001) and more ventilator-free days (p = 0.02). Conclusions: Increasing plasma levels of CRP within 48 h of ARDS onset are associated with improved survival, lower organ failure scores, and fewer days of mechanical ventilation. These data appear to be contrary to the established view that CRP is solely a marker of systemic inflammation.

Original languageEnglish (US)
Pages (from-to)471-480
Number of pages10
JournalChest
Volume136
Issue number2
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

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C-Reactive Protein
Blood Proteins
Organ Dysfunction Scores
Mechanical Ventilators
Inflammation
Survival
Mortality
Cerebral Palsy
Artificial Respiration
Survivors
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Bajwa, E. K., Khan, U. A., Januzzi, J. L., Gong, M. N., Thompson, B. T., & Christiani, D. C. (2009). Plasma C-reactive protein levels are associated with improved outcome in ARDS. Chest, 136(2), 471-480. https://doi.org/10.1378/chest.08-2413

Plasma C-reactive protein levels are associated with improved outcome in ARDS. / Bajwa, Ednan K.; Khan, Uzma A.; Januzzi, James L.; Gong, Michelle Ng; Thompson, B. Taylor; Christiani, David C.

In: Chest, Vol. 136, No. 2, 01.08.2009, p. 471-480.

Research output: Contribution to journalArticle

Bajwa, EK, Khan, UA, Januzzi, JL, Gong, MN, Thompson, BT & Christiani, DC 2009, 'Plasma C-reactive protein levels are associated with improved outcome in ARDS', Chest, vol. 136, no. 2, pp. 471-480. https://doi.org/10.1378/chest.08-2413
Bajwa EK, Khan UA, Januzzi JL, Gong MN, Thompson BT, Christiani DC. Plasma C-reactive protein levels are associated with improved outcome in ARDS. Chest. 2009 Aug 1;136(2):471-480. https://doi.org/10.1378/chest.08-2413
Bajwa, Ednan K. ; Khan, Uzma A. ; Januzzi, James L. ; Gong, Michelle Ng ; Thompson, B. Taylor ; Christiani, David C. / Plasma C-reactive protein levels are associated with improved outcome in ARDS. In: Chest. 2009 ; Vol. 136, No. 2. pp. 471-480.
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