Plasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia.

J. Basu, P. R. Palan, S. H. Vermund, G. L. Goldberg, Robert D. Burk, S. L. Romney

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The association of the plasma levels of the essential micronutrients, ascorbic acid and beta-carotene, with smoking and human papillomaviruses (HPV) infection has been studied in 75 women referred to a colposcopy clinic for an abnormal Pap smear. Each patient had a repeat Pap smear and a colposcopically directed biopsy of a visually perceived cervix abnormality. Cervicovaginal lavage specimen and peripheral venous blood sample were obtained for HPV DNA hybridization studies and nutrient analyses, respectively. Samples were obtained and analyzed without knowledge of each woman's clinical status. A group of 45 subjects had histopathologically diagnosed dysplasias of varying grades of severity. Among women with dysplasias, 53.3% were smokers. Of subjects with and of subjects without dysplasias, 66 and 34%, respectively, were positive for HPV infection. The mean plasma reduced ascorbic acid, retinol, and beta-carotene levels between the dysplastic groups were comparable. A strong association with smoking history and plasma reduced ascorbic acid level was note independent of cervical dysplasias or HPV status. The findings underscore the importance of smoking, ascorbic acid, and beta-carotene as nutritional variables, and HPV infection in the pathogenesis of cervical dysplasias.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalCancer Detection and Prevention
Volume15
Issue number3
StatePublished - 1991

Fingerprint

Uterine Cervical Dysplasia
Papillomavirus Infections
beta Carotene
Ascorbic Acid
Smoking
Papanicolaou Test
Colposcopy
Women's Rights
Micronutrients
Therapeutic Irrigation
Vitamin A
Cervix Uteri
History
Biopsy
Food
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Plasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia. / Basu, J.; Palan, P. R.; Vermund, S. H.; Goldberg, G. L.; Burk, Robert D.; Romney, S. L.

In: Cancer Detection and Prevention, Vol. 15, No. 3, 1991, p. 165-170.

Research output: Contribution to journalArticle

Basu, J. ; Palan, P. R. ; Vermund, S. H. ; Goldberg, G. L. ; Burk, Robert D. ; Romney, S. L. / Plasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia. In: Cancer Detection and Prevention. 1991 ; Vol. 15, No. 3. pp. 165-170.
@article{25a135437dde4b32a3d3786a1b8a8d46,
title = "Plasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia.",
abstract = "The association of the plasma levels of the essential micronutrients, ascorbic acid and beta-carotene, with smoking and human papillomaviruses (HPV) infection has been studied in 75 women referred to a colposcopy clinic for an abnormal Pap smear. Each patient had a repeat Pap smear and a colposcopically directed biopsy of a visually perceived cervix abnormality. Cervicovaginal lavage specimen and peripheral venous blood sample were obtained for HPV DNA hybridization studies and nutrient analyses, respectively. Samples were obtained and analyzed without knowledge of each woman's clinical status. A group of 45 subjects had histopathologically diagnosed dysplasias of varying grades of severity. Among women with dysplasias, 53.3{\%} were smokers. Of subjects with and of subjects without dysplasias, 66 and 34{\%}, respectively, were positive for HPV infection. The mean plasma reduced ascorbic acid, retinol, and beta-carotene levels between the dysplastic groups were comparable. A strong association with smoking history and plasma reduced ascorbic acid level was note independent of cervical dysplasias or HPV status. The findings underscore the importance of smoking, ascorbic acid, and beta-carotene as nutritional variables, and HPV infection in the pathogenesis of cervical dysplasias.",
author = "J. Basu and Palan, {P. R.} and Vermund, {S. H.} and Goldberg, {G. L.} and Burk, {Robert D.} and Romney, {S. L.}",
year = "1991",
language = "English (US)",
volume = "15",
pages = "165--170",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Plasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia.

AU - Basu, J.

AU - Palan, P. R.

AU - Vermund, S. H.

AU - Goldberg, G. L.

AU - Burk, Robert D.

AU - Romney, S. L.

PY - 1991

Y1 - 1991

N2 - The association of the plasma levels of the essential micronutrients, ascorbic acid and beta-carotene, with smoking and human papillomaviruses (HPV) infection has been studied in 75 women referred to a colposcopy clinic for an abnormal Pap smear. Each patient had a repeat Pap smear and a colposcopically directed biopsy of a visually perceived cervix abnormality. Cervicovaginal lavage specimen and peripheral venous blood sample were obtained for HPV DNA hybridization studies and nutrient analyses, respectively. Samples were obtained and analyzed without knowledge of each woman's clinical status. A group of 45 subjects had histopathologically diagnosed dysplasias of varying grades of severity. Among women with dysplasias, 53.3% were smokers. Of subjects with and of subjects without dysplasias, 66 and 34%, respectively, were positive for HPV infection. The mean plasma reduced ascorbic acid, retinol, and beta-carotene levels between the dysplastic groups were comparable. A strong association with smoking history and plasma reduced ascorbic acid level was note independent of cervical dysplasias or HPV status. The findings underscore the importance of smoking, ascorbic acid, and beta-carotene as nutritional variables, and HPV infection in the pathogenesis of cervical dysplasias.

AB - The association of the plasma levels of the essential micronutrients, ascorbic acid and beta-carotene, with smoking and human papillomaviruses (HPV) infection has been studied in 75 women referred to a colposcopy clinic for an abnormal Pap smear. Each patient had a repeat Pap smear and a colposcopically directed biopsy of a visually perceived cervix abnormality. Cervicovaginal lavage specimen and peripheral venous blood sample were obtained for HPV DNA hybridization studies and nutrient analyses, respectively. Samples were obtained and analyzed without knowledge of each woman's clinical status. A group of 45 subjects had histopathologically diagnosed dysplasias of varying grades of severity. Among women with dysplasias, 53.3% were smokers. Of subjects with and of subjects without dysplasias, 66 and 34%, respectively, were positive for HPV infection. The mean plasma reduced ascorbic acid, retinol, and beta-carotene levels between the dysplastic groups were comparable. A strong association with smoking history and plasma reduced ascorbic acid level was note independent of cervical dysplasias or HPV status. The findings underscore the importance of smoking, ascorbic acid, and beta-carotene as nutritional variables, and HPV infection in the pathogenesis of cervical dysplasias.

UR - http://www.scopus.com/inward/record.url?scp=0025931551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025931551&partnerID=8YFLogxK

M3 - Article

VL - 15

SP - 165

EP - 170

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

IS - 3

ER -