Planar cell polarity signaling: A common mechanism for cellular polarization

Andreas Jenny, Marek Mlodzik

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Epithelial cells frequently display - in addition to the common apical-basolateral polarity - a polarization within the plane of the epithelium. This is commonly referred to as planar cell polarity (PCP) or tissue polarity. Examples of vertebrate PCP include epithelial patterning in the skin and inner ear, and also the morphogenetic movements of mesenchymal cells during convergent extension at gastrulation. In Drosophila, all adult epithelial structures of the cuticle are polarized within the plane. This review presents recent results and new insights into the molecular mechanisms underlying the establishment of PCP, and compares and contrasts the intriguing similarities between PCP signaling in Drosophila and vertebrates.

Original languageEnglish (US)
Pages (from-to)738-750
Number of pages13
JournalMount Sinai Journal of Medicine
Volume73
Issue number5
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

Cell Polarity
Drosophila
Vertebrates
Gastrulation
Inner Ear
Cell Movement
Epithelium
Epithelial Cells
Skin

Keywords

  • Convergent extension
  • Drosophila
  • Frizzled
  • Mouse
  • Organ of Corti
  • Planar cell polarity
  • Tissue polarity
  • Zebrafish

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Planar cell polarity signaling : A common mechanism for cellular polarization. / Jenny, Andreas; Mlodzik, Marek.

In: Mount Sinai Journal of Medicine, Vol. 73, No. 5, 09.2006, p. 738-750.

Research output: Contribution to journalArticle

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