Place conditioning with the dopamine D1-like receptor agonist SKF 82958 but not SKF 81297 or SKF 77434

Brett S. Abrahams, Jeff D. Rutherford, Paul E. Mallet, Richard J. Beninger

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

While self-administration and place conditioning studies have shown that dopamine D2-like receptor agonists produce reward-related learning, the, effects of dopamine D1-like receptor agonists remain equivocal. The present study tested three dopamine D1-like receptor agonists for their ability to induce a place preference. Like control rats treated with amphetamine (2.0 mg/kg i.p.), rats treated with SKF 82958 (±-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5- tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide; 0.05 but not 0.01, 0.025, 0.075, or 0.10 mg/kg s.c. and/or i.p.) during conditioning showed a significant increase in the amount of time spent on the drug-paired side during the drug free test. Neither SKF 81297 (±-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide; 0.25, 0.50, 1.0, 2.0, and 4.0 mg/kg i.p.) nor SKF 77434 (±-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride; 0.20, 1.0, 5.0, and 10.0 mg/kg i.p.) produced place conditioning. Significant increases in locomotion were seen at some doses of all drugs. Results show for the first time that systemic administration of a dopamine D1-like receptor agonist produces a place preference and are consistent with previous findings showing that dopamine D1-like receptor activation produces reward-related learning.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalEuropean Journal of Pharmacology
Volume343
Issue number2-3
DOIs
Publication statusPublished - Feb 19 1998

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Keywords

  • Dopamine
  • Dopamine D-like like receptor
  • Learning, reward-related
  • Place conditioning
  • SKF 77434
  • SKF 81297
  • SKF 82958

ASJC Scopus subject areas

  • Pharmacology

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