Abstract
While self-administration and place conditioning studies have shown that dopamine D2-like receptor agonists produce reward-related learning, the, effects of dopamine D1-like receptor agonists remain equivocal. The present study tested three dopamine D1-like receptor agonists for their ability to induce a place preference. Like control rats treated with amphetamine (2.0 mg/kg i.p.), rats treated with SKF 82958 (±-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5- tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide; 0.05 but not 0.01, 0.025, 0.075, or 0.10 mg/kg s.c. and/or i.p.) during conditioning showed a significant increase in the amount of time spent on the drug-paired side during the drug free test. Neither SKF 81297 (±-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide; 0.25, 0.50, 1.0, 2.0, and 4.0 mg/kg i.p.) nor SKF 77434 (±-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride; 0.20, 1.0, 5.0, and 10.0 mg/kg i.p.) produced place conditioning. Significant increases in locomotion were seen at some doses of all drugs. Results show for the first time that systemic administration of a dopamine D1-like receptor agonist produces a place preference and are consistent with previous findings showing that dopamine D1-like receptor activation produces reward-related learning.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 111-118 |
| Number of pages | 8 |
| Journal | European Journal of Pharmacology |
| Volume | 343 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Feb 19 1998 |
| Externally published | Yes |
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Keywords
- Dopamine
- Dopamine D-like like receptor
- Learning, reward-related
- Place conditioning
- SKF 77434
- SKF 81297
- SKF 82958
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Place conditioning with the dopamine D1-like receptor agonist SKF 82958 but not SKF 81297 or SKF 77434. / Abrahams, Brett S.; Rutherford, Jeff D.; Mallet, Paul E.; Beninger, Richard J.
In: European Journal of Pharmacology, Vol. 343, No. 2-3, 19.02.1998, p. 111-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Place conditioning with the dopamine D1-like receptor agonist SKF 82958 but not SKF 81297 or SKF 77434
AU - Abrahams, Brett S.
AU - Rutherford, Jeff D.
AU - Mallet, Paul E.
AU - Beninger, Richard J.
PY - 1998/2/19
Y1 - 1998/2/19
N2 - While self-administration and place conditioning studies have shown that dopamine D2-like receptor agonists produce reward-related learning, the, effects of dopamine D1-like receptor agonists remain equivocal. The present study tested three dopamine D1-like receptor agonists for their ability to induce a place preference. Like control rats treated with amphetamine (2.0 mg/kg i.p.), rats treated with SKF 82958 (±-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5- tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide; 0.05 but not 0.01, 0.025, 0.075, or 0.10 mg/kg s.c. and/or i.p.) during conditioning showed a significant increase in the amount of time spent on the drug-paired side during the drug free test. Neither SKF 81297 (±-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide; 0.25, 0.50, 1.0, 2.0, and 4.0 mg/kg i.p.) nor SKF 77434 (±-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride; 0.20, 1.0, 5.0, and 10.0 mg/kg i.p.) produced place conditioning. Significant increases in locomotion were seen at some doses of all drugs. Results show for the first time that systemic administration of a dopamine D1-like receptor agonist produces a place preference and are consistent with previous findings showing that dopamine D1-like receptor activation produces reward-related learning.
AB - While self-administration and place conditioning studies have shown that dopamine D2-like receptor agonists produce reward-related learning, the, effects of dopamine D1-like receptor agonists remain equivocal. The present study tested three dopamine D1-like receptor agonists for their ability to induce a place preference. Like control rats treated with amphetamine (2.0 mg/kg i.p.), rats treated with SKF 82958 (±-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5- tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide; 0.05 but not 0.01, 0.025, 0.075, or 0.10 mg/kg s.c. and/or i.p.) during conditioning showed a significant increase in the amount of time spent on the drug-paired side during the drug free test. Neither SKF 81297 (±-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide; 0.25, 0.50, 1.0, 2.0, and 4.0 mg/kg i.p.) nor SKF 77434 (±-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride; 0.20, 1.0, 5.0, and 10.0 mg/kg i.p.) produced place conditioning. Significant increases in locomotion were seen at some doses of all drugs. Results show for the first time that systemic administration of a dopamine D1-like receptor agonist produces a place preference and are consistent with previous findings showing that dopamine D1-like receptor activation produces reward-related learning.
KW - Dopamine
KW - Dopamine D-like like receptor
KW - Learning, reward-related
KW - Place conditioning
KW - SKF 77434
KW - SKF 81297
KW - SKF 82958
UR - http://www.scopus.com/inward/record.url?scp=0032545994&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032545994&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(97)01531-8
DO - 10.1016/S0014-2999(97)01531-8
M3 - Article
C2 - 9570457
AN - SCOPUS:0032545994
VL - 343
SP - 111
EP - 118
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -