Pituitary hormone responses to meta-chlorophenylpiperazine in panic disorder and healthy control subjects

RenéS S. Kahn, Scott Wetzler, Gregory M. Asnis, Mitchel A. Kling, Raymond F. Suckow, Herman M. van Praag

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The present study reports adrenocorticotropic hormone (ACTH) and prolactin responses after oral administration of 0.25 mg/kg of the serotonin agonist, meta-chlorophenylpiperazine (MCPP), in patients with panic disorder (PD) and in healthy subjects. MCPP blood levels were similar for the two groups, but almost twice as high in males as in females. Female patients had augmented ACTH and prolactin release as compared to healthy females, while ACTH and prolactin release in male patients was similar to that of male controls. These results suggest that female PD patients have hypersensitive serotonin receptors. Moreover, they indicate that pharmacokinetic gender differences may affect challenge studies, and that different doses may be required to study neuroendocrine responses in males and females.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalPsychiatry Research
Volume37
Issue number1
DOIs
StatePublished - Apr 1991

Keywords

  • Serotonin
  • adrenocorticotropic hormone
  • meta-chlorophenylpiperazine
  • panic disorder
  • prolactin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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