Pituitary hormone responses to meta-chlorophenylpiperazine in panic disorder and healthy control subjects

RenéS Kahn, Scott Wetzler, Gregory M. Asnis, Mitchel A. Kling, Raymond F. Suckow, Herman M. van Praag

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The present study reports adrenocorticotropic hormone (ACTH) and prolactin responses after oral administration of 0.25 mg/kg of the serotonin agonist, meta-chlorophenylpiperazine (MCPP), in patients with panic disorder (PD) and in healthy subjects. MCPP blood levels were similar for the two groups, but almost twice as high in males as in females. Female patients had augmented ACTH and prolactin release as compared to healthy females, while ACTH and prolactin release in male patients was similar to that of male controls. These results suggest that female PD patients have hypersensitive serotonin receptors. Moreover, they indicate that pharmacokinetic gender differences may affect challenge studies, and that different doses may be required to study neuroendocrine responses in males and females.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalPsychiatry Research
Volume37
Issue number1
DOIs
StatePublished - 1991

Fingerprint

Pituitary Hormones
Panic Disorder
Healthy Volunteers
Prolactin
Adrenocorticotropic Hormone
Serotonin Receptor Agonists
Serotonin Receptors
Oral Administration
Pharmacokinetics
1-(3-chlorophenyl)piperazine

Keywords

  • adrenocorticotropic hormone
  • meta-chlorophenylpiperazine
  • panic disorder
  • prolactin
  • Serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Pituitary hormone responses to meta-chlorophenylpiperazine in panic disorder and healthy control subjects. / Kahn, RenéS; Wetzler, Scott; Asnis, Gregory M.; Kling, Mitchel A.; Suckow, Raymond F.; van Praag, Herman M.

In: Psychiatry Research, Vol. 37, No. 1, 1991, p. 25-34.

Research output: Contribution to journalArticle

Kahn, RenéS ; Wetzler, Scott ; Asnis, Gregory M. ; Kling, Mitchel A. ; Suckow, Raymond F. ; van Praag, Herman M. / Pituitary hormone responses to meta-chlorophenylpiperazine in panic disorder and healthy control subjects. In: Psychiatry Research. 1991 ; Vol. 37, No. 1. pp. 25-34.
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