Pituitary and ovarian function in women receiving hormonal contraception

Brian L. Cohen, Maurice Katz

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

A study was performed to further evaluate pituitaryovarian function in women receiving an oral contraceptive preparation. Basal hormone levels (follicle stimulating hormone, luteinizing hormone, estradiol and prolactin) and gonadotropic response to gonadotropic releasing hormone were studied in 12 healthy, regularly ovulating women in the early follicular and mid-luteal phases of their menstrual cycle (non-treatment control period). These same uomen were then given NORDETTE (ethinyl estradiol 30 μg + d-Norgestrel 150 μg) cyclically for 3 months. In the third month of treatment, the tests were repeated on day 21, i.e. after 21 active pills, and on day 28, i.e. after 21 active and 7 inactive tablets. On active preparation, basal luteinizing hormone, follicle stimulating hormone and estradiol and gonadotropin response to gonadotropin releasing hormone were significantly suppressed. However, by day 28 (after completion of the inactive tablets), basal gonadotropin and estradiol concentrations and the gonadotropic response to gonadotropic releasing hormone were not significantly different to their pretreatment levels. No consistent change in prolactin concentration occurred as a result of oral contraceptive therapy. These results indicate that the 'active' component of even a relatively lou-dose pill causes considerable suppression of pituitary-ovarian function but that after 7 days of placebo, pituitary function and basal sstradiol secretion have virtually returned to normal.

Original languageEnglish (US)
Pages (from-to)475-487
Number of pages13
JournalContraception
Volume20
Issue number5
DOIs
StatePublished - Nov 1979

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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