Pipradrol conditioned place preference is blocked by SCH23390

Norman M. White; Noboru Hiroi

doi:10.1016/0091-3057(92)90165-C

Pipradrol conditioned place preference is blocked by SCH23390

Norman M. White, Noboru Hiroi

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We investigated the effect of the selective D₁ dopamine antagonist, SCH23390, on the establishment of a pipradrol-conditioned place preference (CPP). Among various doses of pipradrol (6.25-75.0 mg/kg, SC), a CPP was established at 25.0 mg/kg. SCH23390 (0.16 mg/kg, IP) blocked establishment of a CPP by this dose of pipradrol. The results suggest that pipradrol produces a rewarding effect and that this effect may involve activation of D₁dopamine receptors.

Original language	English (US)
Pages (from-to)	377-380
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(92)90165-C
State	Published - Oct 1992

Keywords

Affect
Conditioned place preference
Conditioned reward
D
Dopamine
Motivation
Reinforcement
Reward
SCH23390

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(92)90165-C

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abstract = "We investigated the effect of the selective D1 dopamine antagonist, SCH23390, on the establishment of a pipradrol-conditioned place preference (CPP). Among various doses of pipradrol (6.25-75.0 mg/kg, SC), a CPP was established at 25.0 mg/kg. SCH23390 (0.16 mg/kg, IP) blocked establishment of a CPP by this dose of pipradrol. The results suggest that pipradrol produces a rewarding effect and that this effect may involve activation of D1dopamine receptors.",

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AU - Hiroi, Noboru

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AB - We investigated the effect of the selective D1 dopamine antagonist, SCH23390, on the establishment of a pipradrol-conditioned place preference (CPP). Among various doses of pipradrol (6.25-75.0 mg/kg, SC), a CPP was established at 25.0 mg/kg. SCH23390 (0.16 mg/kg, IP) blocked establishment of a CPP by this dose of pipradrol. The results suggest that pipradrol produces a rewarding effect and that this effect may involve activation of D1dopamine receptors.

KW - Affect

KW - Conditioned place preference

KW - Conditioned reward

KW - D

KW - Dopamine

KW - Motivation

KW - Reinforcement

KW - Reward

KW - SCH23390

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Pipradrol conditioned place preference is blocked by SCH23390

Abstract

Keywords

ASJC Scopus subject areas

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