Pioglitazone increases adiponectin levels in nondiabetic patients with coronary artery disease

Snehal R. Patel, Lynn M. Mailloux, John T. Coppola, Catalin Mindrescu, Cezar S. Staniloae

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

OBJECTIVES: Hypoadiponectinemia is associated with coronary artery disease (CAD). Pioglitazone has been shown to increase levels of adiponectin in diabetic patients. We sought to assess whether administration of pioglitazone to patients with CAD and without diabetes would affect plasma adiponectin levels and endothelial function. METHODS: Seventeen patients with stable CAD and without evidence of diabetes were treated for 12 weeks with pioglitazone hydrochloride 30 mg daily. Adiponectin levels and endothelium-dependent flow-mediated vasodilation (ED-FMD) measurements were obtained pretreatment, posttreatment, and after a 12-week washout period. RESULTS: Treatment with pioglitazone increased adiponectin levels from an average of 10.6 to 21.1 μg/ml (P=0.001) and improved ED-FMD from 4.45 to 8.43% (P=0.001). CONCLUSION: Treatment with pioglitazone increased plasma adiponectin levels and improved ED-FMD in patients with stable CAD and no evidence of diabetes or insulin resistance.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalCoronary Artery Disease
Volume19
Issue number5
DOIs
StatePublished - Aug 1 2008
Externally publishedYes

Keywords

  • Adiponectin
  • Coronary artery disease
  • Endothelial function
  • Pioglitazone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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