Pilot study of resveratrol in older adults with impaired glucose tolerance

Jill P. Crandall, Valerie Oram, Georgeta Trandafirescu, Migdalia Reid, Preeti Kishore, Meredith A. Hawkins, Hillel W. Cohen, Nir Barzilai

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Abstract

Background. Resveratrol, a plant-derived polyphenol, has shown promising effects on insulin sensitivity and glucose tolerance in animal models and is also reported to have cardioprotective properties, but human studies are limited. In a pilot study, we tested the hypothesis that resveratrol improves glucose metabolism and vascular function in older adults with impaired glucose tolerance (IGT).Methods.Ten subjects aged 72 ± 3 years (M ± SD) with IGT were enrolled in a 4-week open-label study of resveratrol (daily dose 1, 1.5, or 2 g). Following a standard mixed meal (110 g carbohydrate, 20 g protein, 20 g fat), we measured 3-hour glucose and insulin area under the curve (AUC), insulin sensitivity (Matsuda index), and secretion (corrected insulin response at 30 minutes). Endothelial function was assessed by reactive hyperemia peripheral arterial tonometry (reactive hyperemia index) before and 90 minutes postmeal. Results did not differ by dose, so data were combined for analysis.Results.At baseline, body mass index was 29 ± 5 kg/m 2, fasting plasma glucose 110 ± 13 mg/dL, and 2-hour glucose 183 ± 33 mg/dL. After 4 weeks of resveratrol, fasting plasma glucose was unchanged, but peak postmeal (185 ± 10 vs 166 ± 9 mg/dL, p =. 003) and 3-hour glucose AUC (469 ± 23 vs 428 ± 19, p =. 001) declined. Matsuda index improved (3.1 ± 0.5 vs 3.8 ± 0.5, p =. 03), and corrected insulin response at 30 minutes was unchanged (0.6 ± 0.1 vs 0.5 ± 0.5, p =. 49). There was a trend toward improved postmeal reactive hyperemia index (baseline vs resveratrol postmeal delta -0.4 ± 0.2 vs 0.2 ± 0.3, p =. 06). Weight, blood pressure, and lipids were unchanged.Conclusions.At doses between 1 and 2 g/day, resveratrol improves insulin sensitivity and postmeal plasma glucose in subjects with IGT. These preliminary findings support the conduct of larger studies to further investigate the effects of resveratrol on metabolism and vascular function.

Original languageEnglish (US)
Pages (from-to)1307-1312
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67
Issue number12
DOIs
StatePublished - Dec 2012

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Glucose Intolerance
Glucose
Hyperemia
Insulin Resistance
Insulin
Area Under Curve
Blood Vessels
Fasting
resveratrol
Manometry
Polyphenols
Meals
Body Mass Index
Animal Models
Fats
Carbohydrates
Blood Pressure
Lipids
Weights and Measures

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

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Pilot study of resveratrol in older adults with impaired glucose tolerance. / Crandall, Jill P.; Oram, Valerie; Trandafirescu, Georgeta; Reid, Migdalia; Kishore, Preeti; Hawkins, Meredith A.; Cohen, Hillel W.; Barzilai, Nir.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 67, No. 12, 12.2012, p. 1307-1312.

Research output: Contribution to journalArticle

Crandall, Jill P. ; Oram, Valerie ; Trandafirescu, Georgeta ; Reid, Migdalia ; Kishore, Preeti ; Hawkins, Meredith A. ; Cohen, Hillel W. ; Barzilai, Nir. / Pilot study of resveratrol in older adults with impaired glucose tolerance. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2012 ; Vol. 67, No. 12. pp. 1307-1312.
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abstract = "Background. Resveratrol, a plant-derived polyphenol, has shown promising effects on insulin sensitivity and glucose tolerance in animal models and is also reported to have cardioprotective properties, but human studies are limited. In a pilot study, we tested the hypothesis that resveratrol improves glucose metabolism and vascular function in older adults with impaired glucose tolerance (IGT).Methods.Ten subjects aged 72 ± 3 years (M ± SD) with IGT were enrolled in a 4-week open-label study of resveratrol (daily dose 1, 1.5, or 2 g). Following a standard mixed meal (110 g carbohydrate, 20 g protein, 20 g fat), we measured 3-hour glucose and insulin area under the curve (AUC), insulin sensitivity (Matsuda index), and secretion (corrected insulin response at 30 minutes). Endothelial function was assessed by reactive hyperemia peripheral arterial tonometry (reactive hyperemia index) before and 90 minutes postmeal. Results did not differ by dose, so data were combined for analysis.Results.At baseline, body mass index was 29 ± 5 kg/m 2, fasting plasma glucose 110 ± 13 mg/dL, and 2-hour glucose 183 ± 33 mg/dL. After 4 weeks of resveratrol, fasting plasma glucose was unchanged, but peak postmeal (185 ± 10 vs 166 ± 9 mg/dL, p =. 003) and 3-hour glucose AUC (469 ± 23 vs 428 ± 19, p =. 001) declined. Matsuda index improved (3.1 ± 0.5 vs 3.8 ± 0.5, p =. 03), and corrected insulin response at 30 minutes was unchanged (0.6 ± 0.1 vs 0.5 ± 0.5, p =. 49). There was a trend toward improved postmeal reactive hyperemia index (baseline vs resveratrol postmeal delta -0.4 ± 0.2 vs 0.2 ± 0.3, p =. 06). Weight, blood pressure, and lipids were unchanged.Conclusions.At doses between 1 and 2 g/day, resveratrol improves insulin sensitivity and postmeal plasma glucose in subjects with IGT. These preliminary findings support the conduct of larger studies to further investigate the effects of resveratrol on metabolism and vascular function.",
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AU - Oram, Valerie

AU - Trandafirescu, Georgeta

AU - Reid, Migdalia

AU - Kishore, Preeti

AU - Hawkins, Meredith A.

AU - Cohen, Hillel W.

AU - Barzilai, Nir

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N2 - Background. Resveratrol, a plant-derived polyphenol, has shown promising effects on insulin sensitivity and glucose tolerance in animal models and is also reported to have cardioprotective properties, but human studies are limited. In a pilot study, we tested the hypothesis that resveratrol improves glucose metabolism and vascular function in older adults with impaired glucose tolerance (IGT).Methods.Ten subjects aged 72 ± 3 years (M ± SD) with IGT were enrolled in a 4-week open-label study of resveratrol (daily dose 1, 1.5, or 2 g). Following a standard mixed meal (110 g carbohydrate, 20 g protein, 20 g fat), we measured 3-hour glucose and insulin area under the curve (AUC), insulin sensitivity (Matsuda index), and secretion (corrected insulin response at 30 minutes). Endothelial function was assessed by reactive hyperemia peripheral arterial tonometry (reactive hyperemia index) before and 90 minutes postmeal. Results did not differ by dose, so data were combined for analysis.Results.At baseline, body mass index was 29 ± 5 kg/m 2, fasting plasma glucose 110 ± 13 mg/dL, and 2-hour glucose 183 ± 33 mg/dL. After 4 weeks of resveratrol, fasting plasma glucose was unchanged, but peak postmeal (185 ± 10 vs 166 ± 9 mg/dL, p =. 003) and 3-hour glucose AUC (469 ± 23 vs 428 ± 19, p =. 001) declined. Matsuda index improved (3.1 ± 0.5 vs 3.8 ± 0.5, p =. 03), and corrected insulin response at 30 minutes was unchanged (0.6 ± 0.1 vs 0.5 ± 0.5, p =. 49). There was a trend toward improved postmeal reactive hyperemia index (baseline vs resveratrol postmeal delta -0.4 ± 0.2 vs 0.2 ± 0.3, p =. 06). Weight, blood pressure, and lipids were unchanged.Conclusions.At doses between 1 and 2 g/day, resveratrol improves insulin sensitivity and postmeal plasma glucose in subjects with IGT. These preliminary findings support the conduct of larger studies to further investigate the effects of resveratrol on metabolism and vascular function.

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