Pilot study of a commercialized human papillomavirus (HPV) genotyping assay: Comparison of HPV risk group to cytology and histology

Philip E. Castle, Mark Sadorra, Francisco Garcia, E. Blair Holladay, Janet Kornegay

Research output: Contribution to journalArticle

32 Scopus citations


We evaluated a commercialized PCR assay, Linear Array, that detects 37 human papillomavirus (HPV) genotypes, using a sample of liquid cytology specimens (n = 534). We found a strong association of an increasing level of HPV risk (HPV type 16 [HPV16] > HPV18 > other carcinogenic types > noacaranogenic types > negative specimens) with increasing severities of cytologic interpretations (PTrend < 0.0005) and histologic diagnoses (PTrend < 0.0005).

Original languageEnglish (US)
Pages (from-to)3915-3917
Number of pages3
JournalJournal of Clinical Microbiology
Issue number11
StatePublished - Nov 1 2006
Externally publishedYes


ASJC Scopus subject areas

  • Microbiology (medical)

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