Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death

Graziella Migliorati, Luciano D'adamio, Germano Coppi, Ildo Nicoletti, Carlo Riccardi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Experiments were performed to analyze the possible effect of the immunomodulating agent Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid) on mouse Natural Killer (NK) cell activity and glucocorticoid hormone(GCH)-induced thymocyte apoptosis. The results indicate that in vivo treatment with Pidotimod (200 mg/Kg ip for 5 days) causes a significant increase in NK activity and in vitro treatment produces a significant reduction of dexamethasone-induced thymocyte apoptosis. This inhibition appears to be dose-dependent and is also evident against TPA or Ca+plus;ionophore-induced apoptosis.

Original languageEnglish (US)
Pages (from-to)737-748
Number of pages12
JournalImmunopharmacology and Immunotoxicology
Volume14
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

pidotimod
Cell death
Thymocytes
Natural Killer Cells
Cell Death
Apoptosis
Population Growth
Ionophores
Dexamethasone
Glucocorticoids
Hormones
Experiments

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death. / Migliorati, Graziella; D'adamio, Luciano; Coppi, Germano; Nicoletti, Ildo; Riccardi, Carlo.

In: Immunopharmacology and Immunotoxicology, Vol. 14, No. 4, 1992, p. 737-748.

Research output: Contribution to journalArticle

Migliorati, Graziella ; D'adamio, Luciano ; Coppi, Germano ; Nicoletti, Ildo ; Riccardi, Carlo. / Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death. In: Immunopharmacology and Immunotoxicology. 1992 ; Vol. 14, No. 4. pp. 737-748.
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