PI3K/Akt Signaling Pathway Ameliorates Oxidative Stress-Induced Apoptosis upon Manganese Exposure in PC12 Cells

Medicine & Life Sciences

• Manganese 100%
• PC12 Cells 95%
• Phosphatidylinositol 3-Kinases 82%
• B-Cell Lymphoma 69%
• Oxidative Stress 61%
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 59%
• Apoptosis 50%
• Malondialdehyde 48%
• Catalase 48%
• Messenger RNA 47%
• Superoxide Dismutase 46%
• Caspase 3 44%
• bcl-2-Associated X Protein 41%
• Protein-Serine-Threonine Kinases 37%
• manganese sulfate 32%
• Proto-Oncogene Proteins c-akt 19%
• Glutathione Peroxidase 17%
• Phosphatidylinositol 3-Kinase 16%
• Real-Time Polymerase Chain Reaction 13%
• Cell Survival 12%
• Western Blotting 11%
• Proteins 6%

Chemical Compounds

• LY294002 76%
• Superoxide 40%
• Neurotoxicity 34%
• Protein 34%
• Neurological Effect 26%
• Phosphatidylinositol 16%
• Threonine 15%
• Cell Viability 13%
• Serine 13%
• Glutathione 12%
• Peroxidase 12%
• Dose 10%
• Sulfate 10%