TY - JOUR
T1 - Physiological effects of obstructive sleep apnea syndrome in childhood
AU - Muzumdar, Hiren
AU - Arens, Raanan
N1 - Funding Information:
Funding support: NIH grants HD-053693 , HL-105212 to Raanan Arens.
PY - 2013/9/15
Y1 - 2013/9/15
N2 - Sleep disordered breathing in children refers to a group of respiratory disorders that occur or are exacerbated during sleep. Obstructive sleep apnea syndrome (OSAS) is one of the most significant disorders in this group. OSAS can present in all age groups from early infancy to adolescent years. The cardinal feature of OSAS is limitation of inspiratory flow and volume during sleep resulting in abnormal gas exchange and/or alteration of sleep patterns. When OSAS is a chronic condition it often results in adverse physiological effects that impact on health and development. The present review discusses genesis of OSAS in children and consequent end organ injury with special emphasis on behavior and cognition, cardiovascular function, autonomic regulation, inflammation, endothelial function and metabolic syndrome.
AB - Sleep disordered breathing in children refers to a group of respiratory disorders that occur or are exacerbated during sleep. Obstructive sleep apnea syndrome (OSAS) is one of the most significant disorders in this group. OSAS can present in all age groups from early infancy to adolescent years. The cardinal feature of OSAS is limitation of inspiratory flow and volume during sleep resulting in abnormal gas exchange and/or alteration of sleep patterns. When OSAS is a chronic condition it often results in adverse physiological effects that impact on health and development. The present review discusses genesis of OSAS in children and consequent end organ injury with special emphasis on behavior and cognition, cardiovascular function, autonomic regulation, inflammation, endothelial function and metabolic syndrome.
KW - Children
KW - Obstructive sleep apnea
KW - Pathophysiology
KW - Physiology
KW - Sleep disordered breathing
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U2 - 10.1016/j.resp.2013.05.006
DO - 10.1016/j.resp.2013.05.006
M3 - Review article
C2 - 23707879
AN - SCOPUS:84884208723
SN - 1569-9048
VL - 188
SP - 370
EP - 382
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 3
ER -