Physical properties of compounds promoting oral delivery of macromolecular drugs

Ruel Z B Desamero, Hu Cheng, Sean M. Cahill, Mark Girvin, Hua Deng, Robert Callender, Parshuram Rath, Bruce Variano, John E. Smart

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The spectroscopic and solution properties of a series of amidated acids (delivery agents), which promote the gastrointestinal absorption of USP heparin and other drugs that show poor oral bioavailability, are investigated using Raman and NMR spectroscopy. The results show evidence for self-association at low concentrations of delivery agents that increases as the concentration of the delivery agent is increased. The self-associate is characterized by ring-ring stacking interactions, and the best geometrical arrangement for the stacking is the parallel-shifted arrangement of the rings. In addition, the amide group participates in the formation of intermolecular hydrogen bonds in the self-associate. Unlike the rigid ring, the tails of these delivery agents remain relatively flexible in the self-associate. It is suggested that the limited solubility of the delivery agents at physiological pH arises from a percentage of protonated carboxyls. Their presence promotes the formation of intermolecular hydrophobic and ring stacking interactions, which are otherwise weakened by an ionized carboxyl group.

Original languageEnglish (US)
Pages (from-to)26-40
Number of pages15
JournalBiopolymers - Biospectroscopy Section
Volume67
Issue number1
DOIs
StatePublished - 2002

Fingerprint

Raman Spectrum Analysis
Amides
Solubility
Biological Availability
Heparin
Hydrogen
Magnetic Resonance Spectroscopy
Physical properties
Acids
Pharmaceutical Preparations
Nuclear magnetic resonance spectroscopy
Raman spectroscopy
Hydrogen bonds
Gastrointestinal Absorption
Association reactions

Keywords

  • Amidated acids
  • Macromolecular drugs
  • Oral delivery
  • Physical properties

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics

Cite this

Physical properties of compounds promoting oral delivery of macromolecular drugs. / Desamero, Ruel Z B; Cheng, Hu; Cahill, Sean M.; Girvin, Mark; Deng, Hua; Callender, Robert; Rath, Parshuram; Variano, Bruce; Smart, John E.

In: Biopolymers - Biospectroscopy Section, Vol. 67, No. 1, 2002, p. 26-40.

Research output: Contribution to journalArticle

Desamero, Ruel Z B ; Cheng, Hu ; Cahill, Sean M. ; Girvin, Mark ; Deng, Hua ; Callender, Robert ; Rath, Parshuram ; Variano, Bruce ; Smart, John E. / Physical properties of compounds promoting oral delivery of macromolecular drugs. In: Biopolymers - Biospectroscopy Section. 2002 ; Vol. 67, No. 1. pp. 26-40.
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