Phthalates and the diets of US children and adolescents

Leonardo Trasande, Sheela Sathyanarayana, Mary Jo Messito, Rachel S. Gross, Teresa M. Attina, Alan L. Mendelsohn

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Di-2-ethylhexylphthalate (DEHP) is an ester of phthalic acid commonly found in processed foods. DEHP may contribute to obesity and insulin resistance in children and adolescents, yet dietary exposures have been not been studied in this vulnerable subpopulation. Objective: To assess diet and its relation to urinary phthalates in a nationally representative sample of US children and adolescents. Design: Cross-sectional analysis of 24-h dietary recall and urinary phthalate metabolites from 2743 6-19 year olds participating in the 2003-8 National Health and Nutrition Examination Surveys. Regression analyses examined relationships of food consumption with log-transformed metabolite concentrations, examined as low-molecular weight, high molecular weight and di-2-ethylhexylphthalate categories, controlling for urinary creatinine, age group, body mass index category, race/ethnicity, caloric intake and gender. Results: We identified a -0.04% (95% CI: -0.08, -0.01) increment in di-2-ethylhexylphthalate metabolite concentration/additional gram fruit consumption, a +0.01% increment/additional calorie dietary intake (95% CI: +0.003, +0.02), and a +0.09% (95% CI: +0.02, +0.17) increment/additional gram meat/poultry/fish consumption. Soy consumption (-0.40% increment/additional gram consumed, 95% CI: -0.66, -0.14) was inversely associated with di-2-ethylhexylphthalate, while poultry (+0.23% increment/additional gram consumed, 95% CI: +0.12, +0.35) was positively associated. Findings were robust to examination of metabolite concentrations per unit body mass index and weight, and inclusion of fasting time. Conclusions: Diet contributes to urinary phthalate concentrations in children and adolescents. Further study is needed to examine the implications of di-2-ethylhexylphthalate exposure, especially earlier in life, when more permanent metabolic changes may occur.

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalEnvironmental Research
Volume126
DOIs
StatePublished - Oct 2013

Fingerprint

Diethylhexyl Phthalate
phthalate
Nutrition
metabolite
diet
Metabolites
Diet
poultry
body mass
Poultry
health and nutrition
fasting
obesity
food consumption
Body Mass Index
ethnicity
Processed foods
Molecular Weight
subpopulation
Molecular weight

Keywords

  • Children
  • Diet
  • Insulin resistance
  • Obesity
  • Phthalates

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Trasande, L., Sathyanarayana, S., Jo Messito, M., S. Gross, R., Attina, T. M., & Mendelsohn, A. L. (2013). Phthalates and the diets of US children and adolescents. Environmental Research, 126, 84-90. https://doi.org/10.1016/j.envres.2013.07.007

Phthalates and the diets of US children and adolescents. / Trasande, Leonardo; Sathyanarayana, Sheela; Jo Messito, Mary; S. Gross, Rachel; Attina, Teresa M.; Mendelsohn, Alan L.

In: Environmental Research, Vol. 126, 10.2013, p. 84-90.

Research output: Contribution to journalArticle

Trasande, L, Sathyanarayana, S, Jo Messito, M, S. Gross, R, Attina, TM & Mendelsohn, AL 2013, 'Phthalates and the diets of US children and adolescents', Environmental Research, vol. 126, pp. 84-90. https://doi.org/10.1016/j.envres.2013.07.007
Trasande L, Sathyanarayana S, Jo Messito M, S. Gross R, Attina TM, Mendelsohn AL. Phthalates and the diets of US children and adolescents. Environmental Research. 2013 Oct;126:84-90. https://doi.org/10.1016/j.envres.2013.07.007
Trasande, Leonardo ; Sathyanarayana, Sheela ; Jo Messito, Mary ; S. Gross, Rachel ; Attina, Teresa M. ; Mendelsohn, Alan L. / Phthalates and the diets of US children and adolescents. In: Environmental Research. 2013 ; Vol. 126. pp. 84-90.
@article{acf214c3b261432dab5e2771310a1a38,
title = "Phthalates and the diets of US children and adolescents",
abstract = "Background: Di-2-ethylhexylphthalate (DEHP) is an ester of phthalic acid commonly found in processed foods. DEHP may contribute to obesity and insulin resistance in children and adolescents, yet dietary exposures have been not been studied in this vulnerable subpopulation. Objective: To assess diet and its relation to urinary phthalates in a nationally representative sample of US children and adolescents. Design: Cross-sectional analysis of 24-h dietary recall and urinary phthalate metabolites from 2743 6-19 year olds participating in the 2003-8 National Health and Nutrition Examination Surveys. Regression analyses examined relationships of food consumption with log-transformed metabolite concentrations, examined as low-molecular weight, high molecular weight and di-2-ethylhexylphthalate categories, controlling for urinary creatinine, age group, body mass index category, race/ethnicity, caloric intake and gender. Results: We identified a -0.04{\%} (95{\%} CI: -0.08, -0.01) increment in di-2-ethylhexylphthalate metabolite concentration/additional gram fruit consumption, a +0.01{\%} increment/additional calorie dietary intake (95{\%} CI: +0.003, +0.02), and a +0.09{\%} (95{\%} CI: +0.02, +0.17) increment/additional gram meat/poultry/fish consumption. Soy consumption (-0.40{\%} increment/additional gram consumed, 95{\%} CI: -0.66, -0.14) was inversely associated with di-2-ethylhexylphthalate, while poultry (+0.23{\%} increment/additional gram consumed, 95{\%} CI: +0.12, +0.35) was positively associated. Findings were robust to examination of metabolite concentrations per unit body mass index and weight, and inclusion of fasting time. Conclusions: Diet contributes to urinary phthalate concentrations in children and adolescents. Further study is needed to examine the implications of di-2-ethylhexylphthalate exposure, especially earlier in life, when more permanent metabolic changes may occur.",
keywords = "Children, Diet, Insulin resistance, Obesity, Phthalates",
author = "Leonardo Trasande and Sheela Sathyanarayana and {Jo Messito}, Mary and {S. Gross}, Rachel and Attina, {Teresa M.} and Mendelsohn, {Alan L.}",
year = "2013",
month = "10",
doi = "10.1016/j.envres.2013.07.007",
language = "English (US)",
volume = "126",
pages = "84--90",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Phthalates and the diets of US children and adolescents

AU - Trasande, Leonardo

AU - Sathyanarayana, Sheela

AU - Jo Messito, Mary

AU - S. Gross, Rachel

AU - Attina, Teresa M.

AU - Mendelsohn, Alan L.

PY - 2013/10

Y1 - 2013/10

N2 - Background: Di-2-ethylhexylphthalate (DEHP) is an ester of phthalic acid commonly found in processed foods. DEHP may contribute to obesity and insulin resistance in children and adolescents, yet dietary exposures have been not been studied in this vulnerable subpopulation. Objective: To assess diet and its relation to urinary phthalates in a nationally representative sample of US children and adolescents. Design: Cross-sectional analysis of 24-h dietary recall and urinary phthalate metabolites from 2743 6-19 year olds participating in the 2003-8 National Health and Nutrition Examination Surveys. Regression analyses examined relationships of food consumption with log-transformed metabolite concentrations, examined as low-molecular weight, high molecular weight and di-2-ethylhexylphthalate categories, controlling for urinary creatinine, age group, body mass index category, race/ethnicity, caloric intake and gender. Results: We identified a -0.04% (95% CI: -0.08, -0.01) increment in di-2-ethylhexylphthalate metabolite concentration/additional gram fruit consumption, a +0.01% increment/additional calorie dietary intake (95% CI: +0.003, +0.02), and a +0.09% (95% CI: +0.02, +0.17) increment/additional gram meat/poultry/fish consumption. Soy consumption (-0.40% increment/additional gram consumed, 95% CI: -0.66, -0.14) was inversely associated with di-2-ethylhexylphthalate, while poultry (+0.23% increment/additional gram consumed, 95% CI: +0.12, +0.35) was positively associated. Findings were robust to examination of metabolite concentrations per unit body mass index and weight, and inclusion of fasting time. Conclusions: Diet contributes to urinary phthalate concentrations in children and adolescents. Further study is needed to examine the implications of di-2-ethylhexylphthalate exposure, especially earlier in life, when more permanent metabolic changes may occur.

AB - Background: Di-2-ethylhexylphthalate (DEHP) is an ester of phthalic acid commonly found in processed foods. DEHP may contribute to obesity and insulin resistance in children and adolescents, yet dietary exposures have been not been studied in this vulnerable subpopulation. Objective: To assess diet and its relation to urinary phthalates in a nationally representative sample of US children and adolescents. Design: Cross-sectional analysis of 24-h dietary recall and urinary phthalate metabolites from 2743 6-19 year olds participating in the 2003-8 National Health and Nutrition Examination Surveys. Regression analyses examined relationships of food consumption with log-transformed metabolite concentrations, examined as low-molecular weight, high molecular weight and di-2-ethylhexylphthalate categories, controlling for urinary creatinine, age group, body mass index category, race/ethnicity, caloric intake and gender. Results: We identified a -0.04% (95% CI: -0.08, -0.01) increment in di-2-ethylhexylphthalate metabolite concentration/additional gram fruit consumption, a +0.01% increment/additional calorie dietary intake (95% CI: +0.003, +0.02), and a +0.09% (95% CI: +0.02, +0.17) increment/additional gram meat/poultry/fish consumption. Soy consumption (-0.40% increment/additional gram consumed, 95% CI: -0.66, -0.14) was inversely associated with di-2-ethylhexylphthalate, while poultry (+0.23% increment/additional gram consumed, 95% CI: +0.12, +0.35) was positively associated. Findings were robust to examination of metabolite concentrations per unit body mass index and weight, and inclusion of fasting time. Conclusions: Diet contributes to urinary phthalate concentrations in children and adolescents. Further study is needed to examine the implications of di-2-ethylhexylphthalate exposure, especially earlier in life, when more permanent metabolic changes may occur.

KW - Children

KW - Diet

KW - Insulin resistance

KW - Obesity

KW - Phthalates

UR - http://www.scopus.com/inward/record.url?scp=84885860379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885860379&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2013.07.007

DO - 10.1016/j.envres.2013.07.007

M3 - Article

C2 - 24041780

AN - SCOPUS:84885860379

VL - 126

SP - 84

EP - 90

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -