Philadelphia chromosome positive essential thrombocythemia evolving into lymphoid blast crisis

Elisabeth Paietta, Norman Rosen, Michael Roberts, Peter Papenhausen, Peter H. Wiernik

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The Philadelphia chromosome with the classic translocation t(9;22) was detected in all metaphases of a patient with essential thrombocythemia who presented without hematologic signs of chronic myeloid leukemia (CML). After 12 months of treatment with hydroxyurea followed by 6 months of busulfan, the disease transformed into lymphoid blast crisis with the immunophenotype of pre-pre-B cells frequently seen in lymphoid blast crisis of CML. This progression was not associated with karyotypic evolution because lymphoblasts contained only the Philadelphia chromosome. Further clinical course in this patient confirmed the development of a Philadelphia chromosome positive stem cell with predominantly megakaryocytic committment through partially megakaryocytic/lymphoid differentiation to purely lymphoid committment, a previously unreported transformation.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume25
Issue number2
DOIs
StatePublished - Apr 1987

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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