Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

Streamson C. Chua, Jr., Wendy K. Chung, X. Sharon Wu-Peng, Yiying Zhang, Shun Mei Liu, Louis Tartaglia, Rudolph L. Leibel

Research output: Contribution to journalArticle

980 Citations (Scopus)

Abstract

Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob, and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis. Here it is shown by genetic mapping and genomic analysis that mouse db, rat fatty (a homolog of db), and the gene encoding the OB-R are the same gene.

Original languageEnglish (US)
Pages (from-to)994-996
Number of pages3
JournalScience
Volume271
Issue number5251
StatePublished - Feb 16 1996
Externally publishedYes

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Leptin Receptors
Phenotype
Mutation
Genes
vpr Genes
Leptin
Organism Cloning
Body Weight
Ligands
Brain
Proteins

ASJC Scopus subject areas

  • General

Cite this

Chua, Jr., S. C., Chung, W. K., Wu-Peng, X. S., Zhang, Y., Liu, S. M., Tartaglia, L., & Leibel, R. L. (1996). Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science, 271(5251), 994-996.

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. / Chua, Jr., Streamson C.; Chung, Wendy K.; Wu-Peng, X. Sharon; Zhang, Yiying; Liu, Shun Mei; Tartaglia, Louis; Leibel, Rudolph L.

In: Science, Vol. 271, No. 5251, 16.02.1996, p. 994-996.

Research output: Contribution to journalArticle

Chua, Jr., SC, Chung, WK, Wu-Peng, XS, Zhang, Y, Liu, SM, Tartaglia, L & Leibel, RL 1996, 'Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor', Science, vol. 271, no. 5251, pp. 994-996.
Chua, Jr. SC, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 1996 Feb 16;271(5251):994-996.
Chua, Jr., Streamson C. ; Chung, Wendy K. ; Wu-Peng, X. Sharon ; Zhang, Yiying ; Liu, Shun Mei ; Tartaglia, Louis ; Leibel, Rudolph L. / Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. In: Science. 1996 ; Vol. 271, No. 5251. pp. 994-996.
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