Phenelzine vs atenolol in social phobia - A placebo-controlled comparison

Michael R. Liebowitz, Frank Schneier, Raphael Campeas, Eric Hollander, Julie Hatterer, Abby Fyer, Jack Gorman, Laslo Papp, Sharon Davies, Robert Gully, Donald F. Klein

Research output: Contribution to journalArticle

405 Scopus citations

Abstract

Seventy-four patients who met DSM-III criteria for social phobia completed 8 weeks of double-blind, randomly assigned treatment with the monoamine oxidase inhibitor phenelzine sulfate, the cardioselective β-adrenergic blocker atenolol, or placebo. The overall response rates were 64% for phenelzine, 30% for atenolol, and 23% for placebo. Phenelzine was widely superior to both atenolol and placebo on independent rater analyses and, to a lesser extent, on self-report, with no significant differences between atenolol and placebo. At the end of 16 weeks, phenelzine was still significantly superior to placebo, while atenolol showed an intermediate response that did not differ significantly from either of the other treatments. Patients with generalized social phobia constituted 76% of the sample, and they were preferentially responsive to phenelzine. The small size of the discrete social phobic sample precluded separate outcome analyses for this subtype. Overall, the findings support the responsivity of social phobia to monoamine oxidase inhibitors.

Original languageEnglish (US)
Pages (from-to)290-300
Number of pages11
JournalArchives of General Psychiatry
Volume49
Issue number4
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Liebowitz, M. R., Schneier, F., Campeas, R., Hollander, E., Hatterer, J., Fyer, A., Gorman, J., Papp, L., Davies, S., Gully, R., & Klein, D. F. (1992). Phenelzine vs atenolol in social phobia - A placebo-controlled comparison. Archives of General Psychiatry, 49(4), 290-300. https://doi.org/10.1001/archpsyc.49.4.290