Abstract
Fifty-two patients with non-small cell carcinoma of the lung were treated iv with doses of vindesine at 3-4 mg/m2/week iv. Partial responses occurred in all histologic types in ten of 46 adequately treated patients, for an overall response rate of 22%. Patients not previously treated with chemotherapy had a higher response rate than those who had received prior chemotherapy (33% versus 12%). Reversible peripheral neuropathy occurred in all patients, and was generally of a mild to moderate degree. Mild leukopenia was seen frequently, with a median wbc nadir of 2900/mm3. As reported with the older vinca alkaloids, platelet-sparing with occasional episodes of thromboyctosis occurred with vindesine. It is concluded that vindesine is an active agent in non-small cell carcinoma of the lung and that further studies in previously untreated patients are indicated.
Original language | English (US) |
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Pages (from-to) | 1343-1346 |
Number of pages | 4 |
Journal | Cancer Treatment Reports |
Volume | 63 |
Issue number | 8 |
State | Published - 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research