Phase IB trial for malignant melanoma using R24 monoclonal antibody, interleukin-2/α-interferon

R. Katherine Alpaugh, Margaret Von Mehren, Irma Palazzo, Michael B. Atkins, Joseph A. Sparano, Lynn Schuchter, Louis M. Weiner, Janice P. Dutcher

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The inflammatory tumor lymphocytic infiltrates and spontaneous tumor regressions seen in patients with metastatic malignant melanomas suggest a cellular immune involvement. Enhancement of such responses has been the goal of R24 (GD3 ganglioside-specific) monoclonal antibody trials, alone and in combination with other agents. This study reports the results of 21 patients treated in a phase lB trial employing R24 (0, 5, 25, 50 mg/m2) administered by continuous i.v. infusion on days 1-5 followed by 3 Mu each of interleukin- 2 (IL-2) and alpha interferon (α-IFN) given subcutaneously on days 8-12, 15- 19 and 22-26. R24-related toxicities occurred pre-dominantly at the 25 and 50 mg/m2 doses. One patient (50 mg/m2 R24) exhibited a dose-limiting Grade 4 anaphylaxis. Cytokine-related toxicities required IL-2/α-IFN dose reduction in two patients and early termination of treatment in five additional patients. Nine of 20 baseline biopsies showed chronic inflammation; six with lymphocytic tumor infiltration and three where inflammation was confined to the perivascular/peritumoral spaces. No day 8 or 29 biopsies in the R24- treated groups demonstrated treatment-induced tumor lymphocytic infiltrates. However, one patient randomized to no R24 treatment, showed a significant inflammatory tumor lymphocytic infiltration at days 8 and 29. Eighteen of 21 treated patients were evaluable for response. One (5%) patient receiving IL- 2/α-IFN alone had stable disease lasting 1.5 years. Five (28%) R24, IL- 2/α-IFN-treated patients had stable disease ranging from 6 to 32 weeks, with one patient remaining alive 2.5 years post-treatment. Although this combined treatment program was generally well tolerated, no objective responses were seen and significant R24-induced tumor lymphocytic infiltrates were not demonstrated.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalMedical Oncology
Volume15
Issue number3
DOIs
StatePublished - Sep 1998

Keywords

  • IL-2
  • Melanoma
  • Monoclonal antibody
  • R24
  • α-IFN

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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