@article{c10681ebebee4388aa9fb3fbf88a80cf,
title = "Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment",
abstract = "Fragile X syndrome is the leading single gene cause of intellectual disabilities. Treatment of a Drosophila model of Fragile X syndrome with metabotropic glutamate receptor (mGluR) antagonists or lithium rescues social and cognitive impairments. A hallmark feature of the Fragile X mouse model is enhanced mGluR-dependent long-term depression (LTD) at Schaffer collateral to CA1 pyramidal synapses of the hippocampus. Here we examine the effects of chronic treatment of Fragile X mice in vivo with lithium or a group II mGluR antagonist on mGluR-LTD at CA1 synapses. We find that long-term lithium treatment initiated during development (5-6 weeks of age) and continued throughout the lifetime of the Fragile X mice until 9-11 months of age restores normal mGluR-LTD. Additionally, chronic short-term treatment beginning in adult Fragile X mice (8 weeks of age) with either lithium or an mGluR antagonist is also able to restore normal mGluR-LTD. Translating the findings of successful pharmacologic intervention from the Drosophila model into the mouse model of Fragile X syndrome is an important advance, in that this identifies and validates these targets as potential therapeutic interventions for the treatment of individuals afflicted with Fragile X syndrome.",
keywords = "Fragile X syndrome, LY341495, Lithium, Long-term depression, Metabotropic glutamate receptor",
author = "Choi, {Catherine H.} and Schoenfeld, {Brian P.} and Bell, {Aaron J.} and Paul Hinchey and Maria Kollaros and Gertner, {Michael J.} and Woo, {Newton H.} and Tranfaglia, {Michael R.} and Bear, {Mark F.} and Zukin, {R. Suzanne} and McDonald, {Thomas V.} and Jongens, {Thomas A.} and McBride, {Sean M.J.}",
note = "Funding Information: We would like to thank Myles Akabas, Allison Terlizzi, Neal Ferrick, Thomas Dockendorff, Pablo Castillo, Graham Ellis-Davies, Eric Koenigsberg, Alex Harris, Boris Heifets, Kanji Takahashi, Diana Petit, Randi Hagerman, David Nelson, Peter Davies, Peter Klein, Peter Vanderklish, Eric Klann, and Sumantra Chattarji for critical comments during this project. We would like to thank Melanie Talent for the use of space and equipment. We would like to thank the Animal Care Facility at Drexel College of Medicine and Albert Einstein College of Medicine; specifically, we would like to thank Janet Schulenberg, Andy Nelson, Charlene Glenn, and Carlton Reed for assistance with animal care. We would like to acknowledge funding from the FRAXA Research Foundation to S.M.J.M., C.H.C., and T.A.J. We thank the National Fragile X Foundation for a summer fellowship award to Eric Koenigsberg. We would like to acknowledge funding from Autism Speaks to T.V.M and S.M.J.M. We would like to thank the Albert Einstein College of Medicine MSTP grant for funding S.M.J.M and NIH-NINDS and NIGMS funding to T.A.J. The views expressed in the article do not necessarily represent the views of the agency or the United States.",
year = "2011",
month = mar,
day = "22",
doi = "10.1016/j.brainres.2010.11.032",
language = "English (US)",
volume = "1380",
pages = "106--119",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
}