WIRKUNG VON FENDILIN AUF HERZ UND GLATTE MUSKULATUR

Translated title of the contribution: Pharmacological properties of fendiline in cardiac and smooth muscle

W. R. Kubovetz, G. Poech, S. Holzmann, E. Paietta

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The pharmacologic properties of fendiline N(1 phenylethyl[1]) 3,3 diphenylpropylamine hydrochloride, Sensit, were investigated in the isolated guinea pig heart and in isolated circular smooth muscle strips of bovine coronary arteries, pulmonary arteries and trachea. Fendiline dependently increased coronary flow by up to 200% but, in contrast to verapamil, did not inhibit contraction. Fendiline dependently relaxed coronary strips and, more powerfully, tracheal and pulmonary arterial strips. In cardiac muscle, fendiline was almost completely retained for a prolonged period of time. In the smooth muscle tissues under study, fendiline accumulated twenty fold above the concentration present in the organ bath. In paced hearts, fendiline noncompetitively inhibited the positive inotropic effect of isoprenaline in doses that did not significantly depress the amplitude of isotonic contractions. In the guinea pig heart, adenosine uptake became progressively inhibited when the coronary flow increased. This 'washout' effect was definitely counteracted by fendiline and by NaNO2 but was augmented by papaverine, hexobendine and dipyridamol. The counteraction of the 'washout effect' by fendiline as well as by NaNO2 is most likely due to the opening of additional (previously closed) capillaries.

Original languageGerman
Pages (from-to)1321-1330
Number of pages10
JournalArzneimittel-Forschung/Drug Research
Volume26
Issue number7
StatePublished - Dec 1 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Drug Discovery

Cite this

Kubovetz, W. R., Poech, G., Holzmann, S., & Paietta, E. (1976). WIRKUNG VON FENDILIN AUF HERZ UND GLATTE MUSKULATUR. Arzneimittel-Forschung/Drug Research, 26(7), 1321-1330.