Pharmacological, experimental therapeutic, and transcranial magnetic stimulation treatments for compulsivity and impulsivity

Stefano Pallanti, Eric Hollander

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Obsessive-compulsive disorder (OCD) has been recently drawn apart from anxiety disorder by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and clustered together with related disorders (eg, hoarding, hair pulling disorder, skin picking), which with it seems to share clinical and neurophysiological similarities. Recent literature has mainly explored brain circuitries (eg, orbitofrontal cortex, striatum), molecular pathways, and genes (eg, Hoxb8, Slitrk5, Sapap3) that represent the new target of the treatments; they also lead the development of new probes and compounds. In the therapeutic field, monotherapy with cognitive behavioral therapy (CBT) or selective serotonin reuptake inhibitors (SSRIs) is recommendable, but combination or augmentation with a dopaminergic or glutamatergic agent is often adopted. A promising therapy for OCD is represented by repetitive transcranial magnetic stimulation (rTMS), which is suitable to treat compulsivity and impulsivity depending on the protocol of stimulation and the brain circuitries targeted.

Original languageEnglish (US)
Pages (from-to)50-61
Number of pages12
JournalCNS Spectrums
Volume19
Issue number1
DOIs
StatePublished - Feb 2014

Fingerprint

Transcranial Magnetic Stimulation
Impulsive Behavior
Obsessive-Compulsive Disorder
Pharmacology
Excitatory Amino Acid Agents
Dopamine Agents
Serotonin Uptake Inhibitors
Brain
Cognitive Therapy
Prefrontal Cortex
Anxiety Disorders
Diagnostic and Statistical Manual of Mental Disorders
Hair
Therapeutics
Skin
Genes

Keywords

  • impulsivity
  • Keywords Compulsivity
  • obsessive compulsive
  • OCD
  • pharmacotherapy
  • TMS
  • transcranial magnetic stimulation
  • treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Pharmacological, experimental therapeutic, and transcranial magnetic stimulation treatments for compulsivity and impulsivity. / Pallanti, Stefano; Hollander, Eric.

In: CNS Spectrums, Vol. 19, No. 1, 02.2014, p. 50-61.

Research output: Contribution to journalArticle

@article{e5d82b32dde74093913fa089478d9406,
title = "Pharmacological, experimental therapeutic, and transcranial magnetic stimulation treatments for compulsivity and impulsivity",
abstract = "Obsessive-compulsive disorder (OCD) has been recently drawn apart from anxiety disorder by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and clustered together with related disorders (eg, hoarding, hair pulling disorder, skin picking), which with it seems to share clinical and neurophysiological similarities. Recent literature has mainly explored brain circuitries (eg, orbitofrontal cortex, striatum), molecular pathways, and genes (eg, Hoxb8, Slitrk5, Sapap3) that represent the new target of the treatments; they also lead the development of new probes and compounds. In the therapeutic field, monotherapy with cognitive behavioral therapy (CBT) or selective serotonin reuptake inhibitors (SSRIs) is recommendable, but combination or augmentation with a dopaminergic or glutamatergic agent is often adopted. A promising therapy for OCD is represented by repetitive transcranial magnetic stimulation (rTMS), which is suitable to treat compulsivity and impulsivity depending on the protocol of stimulation and the brain circuitries targeted.",
keywords = "impulsivity, Keywords Compulsivity, obsessive compulsive, OCD, pharmacotherapy, TMS, transcranial magnetic stimulation, treatment",
author = "Stefano Pallanti and Eric Hollander",
year = "2014",
month = "2",
doi = "10.1017/S1092852913000618",
language = "English (US)",
volume = "19",
pages = "50--61",
journal = "CNS Spectrums",
issn = "1092-8529",
publisher = "MBL Communications",
number = "1",

}

TY - JOUR

T1 - Pharmacological, experimental therapeutic, and transcranial magnetic stimulation treatments for compulsivity and impulsivity

AU - Pallanti, Stefano

AU - Hollander, Eric

PY - 2014/2

Y1 - 2014/2

N2 - Obsessive-compulsive disorder (OCD) has been recently drawn apart from anxiety disorder by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and clustered together with related disorders (eg, hoarding, hair pulling disorder, skin picking), which with it seems to share clinical and neurophysiological similarities. Recent literature has mainly explored brain circuitries (eg, orbitofrontal cortex, striatum), molecular pathways, and genes (eg, Hoxb8, Slitrk5, Sapap3) that represent the new target of the treatments; they also lead the development of new probes and compounds. In the therapeutic field, monotherapy with cognitive behavioral therapy (CBT) or selective serotonin reuptake inhibitors (SSRIs) is recommendable, but combination or augmentation with a dopaminergic or glutamatergic agent is often adopted. A promising therapy for OCD is represented by repetitive transcranial magnetic stimulation (rTMS), which is suitable to treat compulsivity and impulsivity depending on the protocol of stimulation and the brain circuitries targeted.

AB - Obsessive-compulsive disorder (OCD) has been recently drawn apart from anxiety disorder by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and clustered together with related disorders (eg, hoarding, hair pulling disorder, skin picking), which with it seems to share clinical and neurophysiological similarities. Recent literature has mainly explored brain circuitries (eg, orbitofrontal cortex, striatum), molecular pathways, and genes (eg, Hoxb8, Slitrk5, Sapap3) that represent the new target of the treatments; they also lead the development of new probes and compounds. In the therapeutic field, monotherapy with cognitive behavioral therapy (CBT) or selective serotonin reuptake inhibitors (SSRIs) is recommendable, but combination or augmentation with a dopaminergic or glutamatergic agent is often adopted. A promising therapy for OCD is represented by repetitive transcranial magnetic stimulation (rTMS), which is suitable to treat compulsivity and impulsivity depending on the protocol of stimulation and the brain circuitries targeted.

KW - impulsivity

KW - Keywords Compulsivity

KW - obsessive compulsive

KW - OCD

KW - pharmacotherapy

KW - TMS

KW - transcranial magnetic stimulation

KW - treatment

UR - http://www.scopus.com/inward/record.url?scp=84896719236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896719236&partnerID=8YFLogxK

U2 - 10.1017/S1092852913000618

DO - 10.1017/S1092852913000618

M3 - Article

C2 - 24176028

AN - SCOPUS:84896719236

VL - 19

SP - 50

EP - 61

JO - CNS Spectrums

JF - CNS Spectrums

SN - 1092-8529

IS - 1

ER -