Pharmacological evidence for the presence of a beta-adrenoceptor-like agonist in the amphinomid polychaete Eurythoe complanata

S. O. Suadicani, J. C. de Freitas, M. I. Sawaya

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

1. Methanolic extracts from the body wall of Eurythoe complanata (ExEc) were tested for biological activity on the isolated rat ileum. 2. ExEc produced either relaxation or relaxation followed by contraction of the rat ileum in a concentration-dependent manner. 3. The predominant relaxation response to ExEc was completely blocked by the beta-adrenoceptor antagonist propranolol and was unaffected by the alpha-adrenoceptor antagonist phenoxybenzamine. 4. The results indicate that the relaxation induced by ExEc is mediated by beta-adrenoceptors. The presence of a myorelaxing substance in E. complanata that selectively activates the beta-adrenoceptors is suggested.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume104
Issue number2
DOIs
Publication statusPublished - Feb 1993
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this