Pharmacological approaches to managing migraine and associated comorbidities - Clinical considerations for monotherapy versus polytherapy

Stephen D. Silberstein, David Dodick, Fred Freitag, Starr H. Pearlman, Steven R. Hahn, Ann I. Scher, Richard B. Lipton

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Comorbidity is defined as an illness that occurs more frequently in association with a specific disorder than would be found as a coincidental association in the general population. Conditions that are frequently comorbid with migraine include depression, anxiety, stroke, epilepsy, sleep disorders, and other pain disorders. In addition, many common illnesses occur concomitantly (at the same time) with migraine and influence the treatment choice. Migraine management, and especially migraine prevention, can be challenging when patients have comorbid or concomitant illnesses. The objectives of this initiative are to review the literature on managing patients who have migraine and common comorbidities, present additional clinical approaches for care of these difficult patients, and evaluate the areas in which research is needed to establish evidence-based guidelines for the management of migraine with associated comorbid conditions.

Original languageEnglish (US)
Pages (from-to)585-599
Number of pages15
JournalHeadache
Volume47
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Migraine Disorders
Comorbidity
Pharmacology
Migraine without Aura
Somatoform Disorders
Epilepsy
Patient Care
Anxiety
Stroke
Guidelines
Depression
Research
Population
Therapeutics

Keywords

  • Comorbidity
  • Migraine
  • Monotherapy
  • Polytherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Pharmacological approaches to managing migraine and associated comorbidities - Clinical considerations for monotherapy versus polytherapy. / Silberstein, Stephen D.; Dodick, David; Freitag, Fred; Pearlman, Starr H.; Hahn, Steven R.; Scher, Ann I.; Lipton, Richard B.

In: Headache, Vol. 47, No. 4, 04.2007, p. 585-599.

Research output: Contribution to journalArticle

Silberstein, Stephen D. ; Dodick, David ; Freitag, Fred ; Pearlman, Starr H. ; Hahn, Steven R. ; Scher, Ann I. ; Lipton, Richard B. / Pharmacological approaches to managing migraine and associated comorbidities - Clinical considerations for monotherapy versus polytherapy. In: Headache. 2007 ; Vol. 47, No. 4. pp. 585-599.
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