Pharmacological approaches to managing migraine and associated comorbidities - Clinical considerations for monotherapy versus polytherapy

Stephen D. Silberstein, David Dodick, Fred Freitag, Starr H. Pearlman, Steven R. Hahn, Ann I. Scher, Richard B. Lipton

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

Comorbidity is defined as an illness that occurs more frequently in association with a specific disorder than would be found as a coincidental association in the general population. Conditions that are frequently comorbid with migraine include depression, anxiety, stroke, epilepsy, sleep disorders, and other pain disorders. In addition, many common illnesses occur concomitantly (at the same time) with migraine and influence the treatment choice. Migraine management, and especially migraine prevention, can be challenging when patients have comorbid or concomitant illnesses. The objectives of this initiative are to review the literature on managing patients who have migraine and common comorbidities, present additional clinical approaches for care of these difficult patients, and evaluate the areas in which research is needed to establish evidence-based guidelines for the management of migraine with associated comorbid conditions.

Original languageEnglish (US)
Pages (from-to)585-599
Number of pages15
JournalHeadache
Volume47
Issue number4
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

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Keywords

  • Comorbidity
  • Migraine
  • Monotherapy
  • Polytherapy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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