Pharmacologic Randomized Clinical Trials in Prevention of Type 2 Diabetes

William C. Knowler, Jill P. Crandall

Research output: Contribution to journalReview article

Abstract

Purpose of Review: There have been many randomized clinical trials testing lifestyle and drug interventions to prevent the development of type 2 diabetes in nondiabetic adults at high risk of the disease. We review the major trials using pharmacologic interventions with the primary outcome of preventing diabetes. The trials are grouped according to the main mechanism by which the drugs were thought to have the potential for preventing diabetes. Recent Findings: Drugs in several different classes have been effective in reducing the incidence of diabetes, but evidence for other long-term benefits, such as avoidance of complications and reducing mortality rates, is very limited. Summary: Both drugs and lifestyle interventions are effective in preventing and delaying the onset of type 2 diabetes in high-risk adults. The choices of what drugs to use and when during the development of type 2 diabetes to introduce them are not clear.

Original languageEnglish (US)
Article number154
JournalCurrent Diabetes Reports
Volume19
Issue number12
DOIs
StatePublished - Dec 1 2019

Fingerprint

Type 2 Diabetes Mellitus
Randomized Controlled Trials
Pharmaceutical Preparations
Life Style
Mortality
Incidence

Keywords

  • Pharmacologic prevention
  • Randomized clinical trials
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Pharmacologic Randomized Clinical Trials in Prevention of Type 2 Diabetes. / Knowler, William C.; Crandall, Jill P.

In: Current Diabetes Reports, Vol. 19, No. 12, 154, 01.12.2019.

Research output: Contribution to journalReview article

@article{4a6dd77f1cc0479e8f29fe7a81dcc9ac,
title = "Pharmacologic Randomized Clinical Trials in Prevention of Type 2 Diabetes",
abstract = "Purpose of Review: There have been many randomized clinical trials testing lifestyle and drug interventions to prevent the development of type 2 diabetes in nondiabetic adults at high risk of the disease. We review the major trials using pharmacologic interventions with the primary outcome of preventing diabetes. The trials are grouped according to the main mechanism by which the drugs were thought to have the potential for preventing diabetes. Recent Findings: Drugs in several different classes have been effective in reducing the incidence of diabetes, but evidence for other long-term benefits, such as avoidance of complications and reducing mortality rates, is very limited. Summary: Both drugs and lifestyle interventions are effective in preventing and delaying the onset of type 2 diabetes in high-risk adults. The choices of what drugs to use and when during the development of type 2 diabetes to introduce them are not clear.",
keywords = "Pharmacologic prevention, Randomized clinical trials, Type 2 diabetes",
author = "Knowler, {William C.} and Crandall, {Jill P.}",
year = "2019",
month = "12",
day = "1",
doi = "10.1007/s11892-019-1268-5",
language = "English (US)",
volume = "19",
journal = "Current Diabetes Reports",
issn = "1534-4827",
publisher = "Current Medicine Group",
number = "12",

}

TY - JOUR

T1 - Pharmacologic Randomized Clinical Trials in Prevention of Type 2 Diabetes

AU - Knowler, William C.

AU - Crandall, Jill P.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Purpose of Review: There have been many randomized clinical trials testing lifestyle and drug interventions to prevent the development of type 2 diabetes in nondiabetic adults at high risk of the disease. We review the major trials using pharmacologic interventions with the primary outcome of preventing diabetes. The trials are grouped according to the main mechanism by which the drugs were thought to have the potential for preventing diabetes. Recent Findings: Drugs in several different classes have been effective in reducing the incidence of diabetes, but evidence for other long-term benefits, such as avoidance of complications and reducing mortality rates, is very limited. Summary: Both drugs and lifestyle interventions are effective in preventing and delaying the onset of type 2 diabetes in high-risk adults. The choices of what drugs to use and when during the development of type 2 diabetes to introduce them are not clear.

AB - Purpose of Review: There have been many randomized clinical trials testing lifestyle and drug interventions to prevent the development of type 2 diabetes in nondiabetic adults at high risk of the disease. We review the major trials using pharmacologic interventions with the primary outcome of preventing diabetes. The trials are grouped according to the main mechanism by which the drugs were thought to have the potential for preventing diabetes. Recent Findings: Drugs in several different classes have been effective in reducing the incidence of diabetes, but evidence for other long-term benefits, such as avoidance of complications and reducing mortality rates, is very limited. Summary: Both drugs and lifestyle interventions are effective in preventing and delaying the onset of type 2 diabetes in high-risk adults. The choices of what drugs to use and when during the development of type 2 diabetes to introduce them are not clear.

KW - Pharmacologic prevention

KW - Randomized clinical trials

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85075919094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075919094&partnerID=8YFLogxK

U2 - 10.1007/s11892-019-1268-5

DO - 10.1007/s11892-019-1268-5

M3 - Review article

C2 - 31792721

AN - SCOPUS:85075919094

VL - 19

JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

IS - 12

M1 - 154

ER -