Pharmacokinetics of amikacin, netilmicin and tobramycin in children with chronic renal failure

A. Nayir, A. Sirin, S. Emre, Serife Eti, T. Yesilbek

Research output: Contribution to journalArticle

Abstract

The single-dose pharmacokinetics of amikacin, netilmicin and tobramycin administered intramuscularly at doses of 7.5 mg/kg amikacin, 2.5 mg/kg netilmicin or 3 mg/kg tobramycin were studied in 30 children with chronic renal failure. Serum amikacin, netilmicin and tobramycin levels were measured by a radioimmunoassay method. The correlation between serum creatinine levels and the half-life of the antibiotics was found to be statistically significant. There were interpatient differences in serum aminoglycoside levels among those with the same serum creatinine levels. Thus, monitoring of serum creatinine and aminoglycoside levels is recommended, especially for those with renal failure, in order to maintain an optimal dosage between toxic and noneffective serum aminoglycoside levels.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalTurkish Journal of Pediatrics
Volume37
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

Netilmicin
Tobramycin
Amikacin
Chronic Kidney Failure
Pharmacokinetics
Aminoglycosides
Serum
Creatinine
Poisons
Radioimmunoassay
Renal Insufficiency
Half-Life
Anti-Bacterial Agents

Keywords

  • amikacin
  • chronic renal failure
  • netilmicin
  • pharmacokinetics
  • tobramycin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Pharmacokinetics of amikacin, netilmicin and tobramycin in children with chronic renal failure. / Nayir, A.; Sirin, A.; Emre, S.; Eti, Serife; Yesilbek, T.

In: Turkish Journal of Pediatrics, Vol. 37, No. 2, 1995, p. 111-116.

Research output: Contribution to journalArticle

Nayir, A. ; Sirin, A. ; Emre, S. ; Eti, Serife ; Yesilbek, T. / Pharmacokinetics of amikacin, netilmicin and tobramycin in children with chronic renal failure. In: Turkish Journal of Pediatrics. 1995 ; Vol. 37, No. 2. pp. 111-116.
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